Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis

  • Authors:
    • Weiguo Sui
    • Huan Li
    • Minglin Ou
    • Dong'e Tang
    • Yong Dai
  • View Affiliations

  • Published online on: April 20, 2012     https://doi.org/10.3892/ijmm.2012.975
  • Pages: 173-178
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Abstract

Mesangial proliferative glomerulonephritis (MsPGN) is one of the most common immune-mediated renal diseases. The mesangium is expanded and hypercellular, immuno­globulin deposits can be found in the mesangium, but the mechanism underlying its cause remains largely unclear. There is a large amount of evidence suggesting that long ﹥200 nucleotide) non-coding RNAs (lncRNA) have important regulatory functions in the epigenetic control of gene expression. Multiple lines of evidence increasingly link mutations and dysregulations of lncRNAs to a diverse number of human diseases. Through microarray expression analysis, tests show that thousands of lncRNAs and protein-coding genes are significantly differentially expressed in IgA-negative MsPGN. Some lncRNAs and their neighboring protein-coding genes are closely related and are cooperatively expressed. This may be part of a potential regulatory mechanism. The malfunction of regulation in the network of lncRNAs may be a possible mechanism for the development of IgA-negative MsPGN. Our observations suggest that some lncRNAs are closely related to IgA-negative MsPGN and may be playing an important role in this disease.

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July 2012
Volume 30 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Sui W, Li H, Ou M, Tang D and Dai Y: Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. Int J Mol Med 30: 173-178, 2012
APA
Sui, W., Li, H., Ou, M., Tang, D., & Dai, Y. (2012). Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. International Journal of Molecular Medicine, 30, 173-178. https://doi.org/10.3892/ijmm.2012.975
MLA
Sui, W., Li, H., Ou, M., Tang, D., Dai, Y."Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis". International Journal of Molecular Medicine 30.1 (2012): 173-178.
Chicago
Sui, W., Li, H., Ou, M., Tang, D., Dai, Y."Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis". International Journal of Molecular Medicine 30, no. 1 (2012): 173-178. https://doi.org/10.3892/ijmm.2012.975