Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo

  • Authors:
    • Hui Li
    • Weijue Xu
    • Yimin Huang
    • Xiong Huang
    • Lingcang Xu
    • Zhibao Lv
  • View Affiliations

  • Published online on: September 6, 2012     https://doi.org/10.3892/ijmm.2012.1118
  • Pages: 1081-1086
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Neuroblastoma (NB) is a type of tumor usually found in children under 5 years of age, which originates from lesions in the nervous system and has fast growth and early transformation characteristics. Similar to other cancer types, some typical tumor suppressor genes (TSGs), such as P53 and CHD5 are silenced in NB because of high methylation at promoter zones. In the present study, our results showed that genistein, an element found in soy, is an epigenetic modifier able to decrease hypermethylation levels of CHD5, and enhances the expression of CHD5 as well as p53, possibly contributing to inhibition of NB growth in vivo and tumor microvessel formation. Furthermore, genistein acts as a DNA methyltransferase (DNMT) inhibitor to significantly decrease the expression of DNMT3b. Our study indicates that genistein plays an important role in inhibiting NB growth in vivo, probably preventing tumorigenesis risk as a kind of therapeutic agent for NB treatment in the future.
View Figures
View References

Related Articles

Journal Cover

November 2012
Volume 30 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Xu W, Huang Y, Huang X, Xu L and Lv Z: Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo. Int J Mol Med 30: 1081-1086, 2012
APA
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., & Lv, Z. (2012). Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo. International Journal of Molecular Medicine, 30, 1081-1086. https://doi.org/10.3892/ijmm.2012.1118
MLA
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., Lv, Z."Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo". International Journal of Molecular Medicine 30.5 (2012): 1081-1086.
Chicago
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., Lv, Z."Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo". International Journal of Molecular Medicine 30, no. 5 (2012): 1081-1086. https://doi.org/10.3892/ijmm.2012.1118