Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction

  • Authors:
    • Yang-Gyu Park
    • Jae-Kyo Jeong
    • Ju-Hee Lee
    • You-Jin Lee
    • Jae-Won Seol
    • Shang-Jin Kim
    • Tai-Young Hur
    • Young-Hun Jung
    • Seog-Jin Kang
    • Sang-Youel Park
  • View Affiliations

  • Published online on: November 29, 2012     https://doi.org/10.3892/ijmm.2012.1198
  • Pages: 325-330
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Abstract

Prion disorder-related neurodegenerative diseases are characterized by the accumulation of prion protein (PrP) scrapie isoform (PrPsc) within the central nervous system. PrPsc induces neuronal cell death by increasing intracellular generation of reactive oxygen species (ROS). Lactoferrin (LF) is an 80 kDa protein, which has antioxidant abilities due to the scavenging of ROS. The effects of LF treatment on PrP (106-126)-mediated neurotoxicity and ROS generation were the focus of this study. LF treatment protected against PrP (106-126)-induced neuronal cell death and decreased ROS generation. The reduced ROS generation prevented PrP (106-126)-induced mitochondrial dysfunction. Moreover, PrP (106-126)-induced protein activation including c-Jun N-terminal kinase and caspase-3 were blocked by LF treatment. These results demonstrated that LF protects neuronal cells against PrP (106-126)-mediated neurotoxicity through the scavenging of ROS and provide evidence that LF treatment prevents neuronal cell death caused by PrP (106-126).

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February 2013
Volume 31 Issue 2

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Copy and paste a formatted citation
APA
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S. ... Park, S. (2013). Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction. International Journal of Molecular Medicine, 31, 325-330. https://doi.org/10.3892/ijmm.2012.1198
MLA
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S., Hur, T., Jung, Y., Kang, S., Park, S."Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction". International Journal of Molecular Medicine 31.2 (2013): 325-330.
Chicago
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S., Hur, T., Jung, Y., Kang, S., Park, S."Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction". International Journal of Molecular Medicine 31, no. 2 (2013): 325-330. https://doi.org/10.3892/ijmm.2012.1198