Redox regulation of tumor suppressor PTEN in cancer and aging (Review)

  • Authors:
    • Yasuko Kitagishi
    • Satoru Matsuda
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  • Published online on: January 10, 2013     https://doi.org/10.3892/ijmm.2013.1235
  • Pages: 511-515
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Abstract

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has been shown to act as a tumor suppressor whose function includes important roles in regulating oxidative stress, indicating a potential role in oxidative damage-associated cancer. Accumulating evidence has revealed that PTEN also acts as a pivotal determinant of cell fate, regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. Cells are continuously exposed to ROS, which represent mutagens and are thought to be a major contributor to cancer and the aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, PTEN and the roles of oxidative stress in phosphoinositide-3 kinase/AKT signaling are summarized with a focus on the links between the pathways and ROS in cancer and aging.
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March 2013
Volume 31 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kitagishi Y and Kitagishi Y: Redox regulation of tumor suppressor PTEN in cancer and aging (Review). Int J Mol Med 31: 511-515, 2013
APA
Kitagishi, Y., & Kitagishi, Y. (2013). Redox regulation of tumor suppressor PTEN in cancer and aging (Review). International Journal of Molecular Medicine, 31, 511-515. https://doi.org/10.3892/ijmm.2013.1235
MLA
Kitagishi, Y., Matsuda, S."Redox regulation of tumor suppressor PTEN in cancer and aging (Review)". International Journal of Molecular Medicine 31.3 (2013): 511-515.
Chicago
Kitagishi, Y., Matsuda, S."Redox regulation of tumor suppressor PTEN in cancer and aging (Review)". International Journal of Molecular Medicine 31, no. 3 (2013): 511-515. https://doi.org/10.3892/ijmm.2013.1235