High mobility group box 1 and kidney diseases (Review)

  • Authors:
    • Ping Zhu
    • Li Xie
    • Hua-Sheng Ding
    • Quan Gong
    • Jian Yang
    • Lin Yang
  • View Affiliations

  • Published online on: February 25, 2013     https://doi.org/10.3892/ijmm.2013.1286
  • Pages: 763-768
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Abstract

High mobility group box 1 (HMGB1), a non-histone DNA-binding protein, regulates nucleosome function and transcription in the nuclei of all metazoans and plants. However, extracellular HMGB1, which is actively or passively released under different conditions, can act as a key inflammatory mediator through MyD88/mitogen-activated protein kinase signaling by binding to its receptors including the receptor for advanced glycation end products or Toll-like receptors. A growing body of evidence indicates that HMGB1 plays an important role in kidney diseases, such as glomerulonephritis, lupus nephritis, antineutrophilic cytoplasmatic antibody-associated vaculitis, diabetic nephropathy, renal allograft rejection and acute kidney injury. In this review, we focus on the biology of HMGB1 and the association of HMGB1 with kidney diseases.
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April 2013
Volume 31 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhu P, Xie L, Ding H, Gong Q, Yang J and Yang L: High mobility group box 1 and kidney diseases (Review). Int J Mol Med 31: 763-768, 2013
APA
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., & Yang, L. (2013). High mobility group box 1 and kidney diseases (Review). International Journal of Molecular Medicine, 31, 763-768. https://doi.org/10.3892/ijmm.2013.1286
MLA
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., Yang, L."High mobility group box 1 and kidney diseases (Review)". International Journal of Molecular Medicine 31.4 (2013): 763-768.
Chicago
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., Yang, L."High mobility group box 1 and kidney diseases (Review)". International Journal of Molecular Medicine 31, no. 4 (2013): 763-768. https://doi.org/10.3892/ijmm.2013.1286