Open Access

Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1

  • Authors:
    • Ruth Amann
    • Beat Trueb
  • View Affiliations

  • Published online on: September 10, 2013     https://doi.org/10.3892/ijmm.2013.1484
  • Pages: 983-988
  • Copyright: © Amann et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Fibroblast growth factor (FGF) receptor-like protein 1 (FGFRL1) is a recently discovered member of the FGF receptor (FGFR) family. Similar to the classical FGFRs, it contains three extracellular immunoglobulin‑like domains and interacts with FGF ligands. However, in contrast to the classical receptors, it does not contain any intracellular tyrosine kinase domain and consequently cannot signal by transphosphorylation. In mouse kidneys, FgfrL1 is expressed primarily at embryonic stages E14-E15 in regions where nascent nephrons develop. In this study, we used whole-mount in situ hybridization to show the spatial pattern of five different Fgfrs in the developing mouse kidney. We compared the expression pattern of FgfrL1 with that of other Fgfrs. The expression pattern of FgfrL1 closely resembled that of Fgfr1, but clearly differed from that of Fgfr2‑Fgfr4. It is therefore conceivable that FgfrL1 signals indirectly via Fgfr1. The mechanisms by which FgfrL1 affects the activity of Fgfr1 remain to be elucidated.
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November 2013
Volume 32 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Amann R and Amann R: Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. Int J Mol Med 32: 983-988, 2013
APA
Amann, R., & Amann, R. (2013). Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. International Journal of Molecular Medicine, 32, 983-988. https://doi.org/10.3892/ijmm.2013.1484
MLA
Amann, R., Trueb, B."Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1". International Journal of Molecular Medicine 32.5 (2013): 983-988.
Chicago
Amann, R., Trueb, B."Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1". International Journal of Molecular Medicine 32, no. 5 (2013): 983-988. https://doi.org/10.3892/ijmm.2013.1484