The WWOX tumor suppressor gene in endometrial adenocarcinoma

  • Authors:
    • Elżbieta Płuciennik
    • Katarzyna Kośla
    • Katarzyna Wójcik-Krowiranda
    • Andrzej Bieńkiewicz
    • Andrzej K. Bednarek
  • View Affiliations

  • Published online on: October 11, 2013     https://doi.org/10.3892/ijmm.2013.1526
  • Pages: 1458-1464
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Abstract

Endometrial cancer is a lethal malignancy, the causes of which remain to be determined. The aim of the present study, carried out on tumor samples from 79 patients, was to evaluate the role of the WWOX tumor suppressor gene in endometrial adenocarcinoma. The expression levels of WWOX and its protein content were assessed in normal endometrium and cancer samples. Quantitative PCR was used to assess the correlation between the expression levels of WWOX and the genes involved in the proliferation (MKI67), apoptosis (BAX, BCL2), signal transduction (EGFR), cell cycle (CCNE1, CCND1), cell adhesion (CDH1) and transcription regulation (TP73, NCOR1). The relationship between loss of hetero­zygosity (LOH) and WWOX mRNA levels was also investigated using high resolution melting. Results of the present study demonstrated a positive correlation of WWOX expression with BCL2 and CCND1 and a negative correlation with BAX, CDH1, NCOR1 and BCL2/BAX ratio. The results also showed that loss of heterozygosity at two analyzed loci of the WWOX gene is frequent in patients with endometrial cancer and that WWOX expression levels are lower in tumor samples than in normal tissue. In conclusion, WWOX may be involved in endometrial cancer.
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December 2013
Volume 32 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Płuciennik E, Kośla K, Wójcik-Krowiranda K, Bieńkiewicz A and Bednarek AK: The WWOX tumor suppressor gene in endometrial adenocarcinoma. Int J Mol Med 32: 1458-1464, 2013
APA
Płuciennik, E., Kośla, K., Wójcik-Krowiranda, K., Bieńkiewicz, A., & Bednarek, A.K. (2013). The WWOX tumor suppressor gene in endometrial adenocarcinoma. International Journal of Molecular Medicine, 32, 1458-1464. https://doi.org/10.3892/ijmm.2013.1526
MLA
Płuciennik, E., Kośla, K., Wójcik-Krowiranda, K., Bieńkiewicz, A., Bednarek, A. K."The WWOX tumor suppressor gene in endometrial adenocarcinoma". International Journal of Molecular Medicine 32.6 (2013): 1458-1464.
Chicago
Płuciennik, E., Kośla, K., Wójcik-Krowiranda, K., Bieńkiewicz, A., Bednarek, A. K."The WWOX tumor suppressor gene in endometrial adenocarcinoma". International Journal of Molecular Medicine 32, no. 6 (2013): 1458-1464. https://doi.org/10.3892/ijmm.2013.1526