Complex interaction between the immune system and adipose tissue (Review)

  • Authors:
    • Sylwia Małgorzewicz
    • Jolanta Anna Dardzińska
    • Maria Gnacińska
    • Jerzy Jankun
    • Ewa Bryl
    • Krzysztof Sworczak
  • View Affiliations

  • Published online on: October 25, 2013     https://doi.org/10.3892/ijmm.2013.1537
  • Pages: 3-7
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Abstract

We review the studies on the links between obesity, the immune system and lifestyle (limited or excessive calorie intake) that provoke changes in the current therapeutic course. There is no doubt that the positive energy balance of the body affects the immune cells, and consequently, the changes intracellular pathways, leading to the disruption of their function. Research suggests that metformin, a drug long used to treat diabetes, and an alternative remedy in the treatment of obesity, increases the activity of 5-adenosinemonophosphate (AMP)-activated kinase (AMPK). Thus, this review comes to the conclusion that alongside traditional methods, such as reducing calorie intake and increasing the energy expenditure of the body, the therapeutic outcome may be improved by implementing drugs affecting the activity of AMPK. In future, other new therapeutic options may be available. The targeting receptors or immunocompetent cells residing in adipose tissue may help to reduce the effects of obesity.
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2014-January
Volume 33 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Małgorzewicz S, Dardzińska JA, Gnacińska M, Jankun J, Bryl E and Sworczak K: Complex interaction between the immune system and adipose tissue (Review). Int J Mol Med 33: 3-7, 2014
APA
Małgorzewicz, S., Dardzińska, J.A., Gnacińska, M., Jankun, J., Bryl, E., & Sworczak, K. (2014). Complex interaction between the immune system and adipose tissue (Review). International Journal of Molecular Medicine, 33, 3-7. https://doi.org/10.3892/ijmm.2013.1537
MLA
Małgorzewicz, S., Dardzińska, J. A., Gnacińska, M., Jankun, J., Bryl, E., Sworczak, K."Complex interaction between the immune system and adipose tissue (Review)". International Journal of Molecular Medicine 33.1 (2014): 3-7.
Chicago
Małgorzewicz, S., Dardzińska, J. A., Gnacińska, M., Jankun, J., Bryl, E., Sworczak, K."Complex interaction between the immune system and adipose tissue (Review)". International Journal of Molecular Medicine 33, no. 1 (2014): 3-7. https://doi.org/10.3892/ijmm.2013.1537