Paracrine control of glucagon release by somatostatin (Review)

  • Authors:
    • Willy J. Malaisse
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  • Published online on: December 24, 2013     https://doi.org/10.3892/ijmm.2013.1605
  • Pages: 491-498
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Abstract

Emphasis was recently placed on the modulation of glucagon secretion attributable to a paracrine effect of somatostatin. This review draws attention to prior findings related to such a view. The effects of nutrient secretagogues upon insulin, somatostatin and glucagon release by the perfused pancreas are first considered. Three examples of paradoxical secretory responses of insulin- and glucagon-producing cells are then given. Further experiments dealing with the possible role of somatostatin upon glucagon release and the relevance of pancreatic compartmentation are also presented. It is concluded that these prior findings provide, within limits, support to the postulated paracrine role of somatostatin in the control of glucagon secretion.
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2014-March
Volume 33 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Malaisse WJ: Paracrine control of glucagon release by somatostatin (Review). Int J Mol Med 33: 491-498, 2014
APA
Malaisse, W.J. (2014). Paracrine control of glucagon release by somatostatin (Review). International Journal of Molecular Medicine, 33, 491-498. https://doi.org/10.3892/ijmm.2013.1605
MLA
Malaisse, W. J."Paracrine control of glucagon release by somatostatin (Review)". International Journal of Molecular Medicine 33.3 (2014): 491-498.
Chicago
Malaisse, W. J."Paracrine control of glucagon release by somatostatin (Review)". International Journal of Molecular Medicine 33, no. 3 (2014): 491-498. https://doi.org/10.3892/ijmm.2013.1605