Atherosclerosis and tumor suppressor molecules (Review)

  • Authors:
    • Miho Suzuki
    • Akari Minami
    • Atsuko Nakanishi
    • Keiko Kobayashi
    • Satoru Matsuda
    • Yasunori Ogura
    • Yasuko Kitagishi
  • View Affiliations

  • Published online on: July 25, 2014     https://doi.org/10.3892/ijmm.2014.1866
  • Pages: 934-940
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Atherosclerosis, the major cause of heart attack and stroke, is a chronic inflammatory disease characterized by the formation of atherosclerotic plaque. Oxidized low-density lipoprotein through increased oxidative stress has been identified as one of the primary factors responsible for atherogenesis. Cell proliferation and death are key processes in the progression of atherosclerosis. The oxidative environment in areas of lipid accumulation is mainly created by the production of reactive oxygen species, which are assumed to mediate vascular tissue injury. Oxidative DNA damage and levels of DNA repair are reduced during dietary lipid lowering. The tumor suppressor molecules play a pivotal role in regulating cell proliferation, DNA repair and cell death, which are important processes in regulating the composition of atherosclerotic plaque. Accordingly, in this review, we discuss the fundamental role of tumor suppressor molecules in regulating atherogenesis. In particular, we discuss how tumor suppressor molecules are activated in the complex environment of atherosclerotic plaque, and regulate growth arrest, cell senescence and the apoptosis of vascular smooth muscle cells, which may protect against the progression of atherosclerosis. In addition, we discuss promising alternatives to the use of medications (such as statin) against atherosclerosis, namely diet, with the use of plant-derived supplements to modulate the expression and/or activity of tumor suppressor molecules. We also summarize the progress of research made on herbs with a focus on the modulatory roles of tumor suppressors, and on the molecular mechanisms underlying the prevention if atherosclerosis, supporting designs for further research in this field.
View Figures
View References

Related Articles

Journal Cover

October 2014
Volume 34 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki M, Minami A, Nakanishi A, Kobayashi K, Matsuda S, Ogura Y and Kitagishi Y: Atherosclerosis and tumor suppressor molecules (Review). Int J Mol Med 34: 934-940, 2014
APA
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., & Kitagishi, Y. (2014). Atherosclerosis and tumor suppressor molecules (Review). International Journal of Molecular Medicine, 34, 934-940. https://doi.org/10.3892/ijmm.2014.1866
MLA
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., Kitagishi, Y."Atherosclerosis and tumor suppressor molecules (Review)". International Journal of Molecular Medicine 34.4 (2014): 934-940.
Chicago
Suzuki, M., Minami, A., Nakanishi, A., Kobayashi, K., Matsuda, S., Ogura, Y., Kitagishi, Y."Atherosclerosis and tumor suppressor molecules (Review)". International Journal of Molecular Medicine 34, no. 4 (2014): 934-940. https://doi.org/10.3892/ijmm.2014.1866