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Transforming growth factor β regulates β-catenin expression in lung fibroblast through NF-κB dependent pathway

  • Authors:
    • Jian Li
    • Gang Wang
    • Xia Sun
  • View Affiliations

  • Published online on: August 27, 2014     https://doi.org/10.3892/ijmm.2014.1916
  • Pages: 1219-1224
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

β-catenin contributes to the pathogenesis of lung fibrosis. However, the expression of β-catenin in fibroblasts under fibrotic conditions has not been studied. We investigated the expression of β-catenin in lung fibroblasts from bleomycin (BLM)‑challenged mice and human lung fibroblasts treated with transforming growth factor β (TGF-β) or lysophosphatidic acid (LPA) by western blot analysis. The result showed that the expression of β-catenin was significantly increased in lung fibrotic foci and lung fibroblasts from bleomycin‑challenged mice. TGF-β stimulated β-catenin expression and induced differentiation in human lung fibroblasts in vitro. Pretreatment of the NF-κB activation inhibitor attenuated the TGF-β‑induced expression of β-catenin and differentiation in human lung fibroblasts. Similarly, LPA induced β-catenin expression in human lung fibroblasts, and pre-treatment of the neutralized anti-TGF-β antibody attenuated the LPA‑induced expression of β-catenin and differentiation in human lung fibroblasts. The results suggested that β-catenin expression is upregulated in lung fibroblast during differentiation, and that TGF-β induced β-catenin expression in human lung fibroblasts through the activation of NF-κB.
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November-2014
Volume 34 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Li J, Wang G and Sun X: Transforming growth factor β regulates β-catenin expression in lung fibroblast through NF-κB dependent pathway. Int J Mol Med 34: 1219-1224, 2014
APA
Li, J., Wang, G., & Sun, X. (2014). Transforming growth factor β regulates β-catenin expression in lung fibroblast through NF-κB dependent pathway. International Journal of Molecular Medicine, 34, 1219-1224. https://doi.org/10.3892/ijmm.2014.1916
MLA
Li, J., Wang, G., Sun, X."Transforming growth factor β regulates β-catenin expression in lung fibroblast through NF-κB dependent pathway". International Journal of Molecular Medicine 34.5 (2014): 1219-1224.
Chicago
Li, J., Wang, G., Sun, X."Transforming growth factor β regulates β-catenin expression in lung fibroblast through NF-κB dependent pathway". International Journal of Molecular Medicine 34, no. 5 (2014): 1219-1224. https://doi.org/10.3892/ijmm.2014.1916