Open Access

Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study

  • Authors:
    • Yoshiji Yamada
    • Kota Matsui
    • Ichiro Takeuchi
    • Mitsutoshi Oguri
    • Tetsuo Fujimaki
  • View Affiliations

  • Published online on: March 20, 2015     https://doi.org/10.3892/ijmm.2015.2151
  • Pages: 1189-1198
  • Copyright: © Yamada et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

We previously identified 9 genes and chromosomal region 3q28 as susceptibility loci for Japanese patients with myocardial infarction, ischemic stroke, or chronic kidney disease by genome-wide or candidate gene association studies. In the present study, we investigated the possible association of 13 single nucleotide polymorphisms (SNPs) at these 10 loci with the prevalence of hypertension or their association with blood pressure (BP) in community-dwelling individuals in Japan. The study subjects comprised 6,027 individuals (2,250 subjects with essential hypertension, 3,777 controls) who were recruited into the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study on atherosclerotic, cardiovascular and metabolic diseases. The subjects were recruited from individuals who visited the Health Care Center of Inabe General Hospital for an annual health checkup, and they are followed up each year (mean follow‑up period, 5 years). Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension. Longitudinal analysis with a generalized linear mixed-effect model and with adjustment for age, gender, body mass index and smoking status among individuals not taking anti-hypertensive medication revealed that rs6929846 of BTN2A1 was significantly associated with systolic (P=0.0017), diastolic (P=0.0008) and mean (P=0.0005) BP, and that rs2116519 of FAM78B, rs146021107 of PDX1 and rs1671021 of LLGL2 were significantly associated with diastolic (P=0.0495), systolic (P=0.0132), and both diastolic (P=0.0468) and mean (0.0471) BP, respectively. BTN2A1 may thus be a susceptibility gene for hypertension.
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May-2015
Volume 35 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. Int J Mol Med 35: 1189-1198, 2015
APA
Yamada, Y., Matsui, K., Takeuchi, I., Oguri, M., & Fujimaki, T. (2015). Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. International Journal of Molecular Medicine, 35, 1189-1198. https://doi.org/10.3892/ijmm.2015.2151
MLA
Yamada, Y., Matsui, K., Takeuchi, I., Oguri, M., Fujimaki, T."Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study". International Journal of Molecular Medicine 35.5 (2015): 1189-1198.
Chicago
Yamada, Y., Matsui, K., Takeuchi, I., Oguri, M., Fujimaki, T."Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study". International Journal of Molecular Medicine 35, no. 5 (2015): 1189-1198. https://doi.org/10.3892/ijmm.2015.2151