Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)

  • Authors:
    • Shujiong Feng
    • Song Xu
    • Zhenzhen Wen
    • Yongliang Zhu
  • View Affiliations

  • Published online on: March 26, 2015     https://doi.org/10.3892/ijmm.2015.2155
  • Pages: 1493-1500
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Abstract

Nuclear receptors are a superfamily of transcription factors including the steroid hormone receptors, non-steroid hormone receptors and the orphan nuclear receptor family. Retinoic acid-related orphan receptor (ROR)β, as a member of the orphan nuclear receptor family, plays an important regulatory role in the maintenance of a variety of physiological and pathological processes. RORβ has been determined to act as an osteogenic repressor in regulating bone formation, and is involved in regulating circadian rhythm. The findings of recent studies concerning the association between tumorigenesis and circadian rhythm have shown that an aberrant circadian rhythm may promote tumorigenesis and tumor progression. The mechanisms discussed in this review demonstrate how aberrant RORβ-induced circadian rhythm may become a new direction for future studies on tumorigenesis and strategy design for cancer prevention.
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June-2015
Volume 35 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Feng S, Xu S, Wen Z and Zhu Y: Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review). Int J Mol Med 35: 1493-1500, 2015
APA
Feng, S., Xu, S., Wen, Z., & Zhu, Y. (2015). Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review). International Journal of Molecular Medicine, 35, 1493-1500. https://doi.org/10.3892/ijmm.2015.2155
MLA
Feng, S., Xu, S., Wen, Z., Zhu, Y."Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)". International Journal of Molecular Medicine 35.6 (2015): 1493-1500.
Chicago
Feng, S., Xu, S., Wen, Z., Zhu, Y."Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)". International Journal of Molecular Medicine 35, no. 6 (2015): 1493-1500. https://doi.org/10.3892/ijmm.2015.2155