Identification of novel targets for the diagnosis and treatment of liver fibrosis

  • Authors:
    • Paolo Fagone
    • Katia Mangano
    • Santa Mammana
    • Antonio Pesce
    • Aurora Pesce
    • Rosario Caltabiano
    • Alexandra Giorlandino
    • Teresa Rosanna Portale
    • Eugenio Cavalli
    • Giuseppe A.G. Lombardo
    • Marinella Coco
    • Stefano Puleo
    • Ferdinando Nicoletti
  • View Affiliations

  • Published online on: June 29, 2015     https://doi.org/10.3892/ijmm.2015.2264
  • Pages: 747-752
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Abstract

Liver fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) in the hepatic parenchyma and represents an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. Hepatic stellate cells (HSCs) are the major cell type responsible for liver fibrosis. Following liver injury, HSCs become activated and transdifferentiate into myofibroblasts (MFBs) that lead to intrahepatic ECM accumulation. In the present study, we performed a meta‑analysis of datasets which included whole-genome transcriptional data on HSCs in the quiescent and activated state from two different rodent species and identified commonly regulated genes. Several of the genes identified, including ECM components, metalloproteinases and growth factors, were found to be well‑known markers for HSC activation. However, other significant genes also appeared to play important roles in hepatic fibrosis. The elucidation of the molecular events underlying HSC activation may be key to the identification of potential novel pharmacological targets for the prevention and treatment of liver fibrosis.
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September-2015
Volume 36 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Fagone P, Mangano K, Mammana S, Pesce A, Pesce A, Caltabiano R, Giorlandino A, Portale TR, Cavalli E, Lombardo GA, Lombardo GA, et al: Identification of novel targets for the diagnosis and treatment of liver fibrosis. Int J Mol Med 36: 747-752, 2015
APA
Fagone, P., Mangano, K., Mammana, S., Pesce, A., Pesce, A., Caltabiano, R. ... Nicoletti, F. (2015). Identification of novel targets for the diagnosis and treatment of liver fibrosis. International Journal of Molecular Medicine, 36, 747-752. https://doi.org/10.3892/ijmm.2015.2264
MLA
Fagone, P., Mangano, K., Mammana, S., Pesce, A., Pesce, A., Caltabiano, R., Giorlandino, A., Portale, T. R., Cavalli, E., Lombardo, G. A., Coco, M., Puleo, S., Nicoletti, F."Identification of novel targets for the diagnosis and treatment of liver fibrosis". International Journal of Molecular Medicine 36.3 (2015): 747-752.
Chicago
Fagone, P., Mangano, K., Mammana, S., Pesce, A., Pesce, A., Caltabiano, R., Giorlandino, A., Portale, T. R., Cavalli, E., Lombardo, G. A., Coco, M., Puleo, S., Nicoletti, F."Identification of novel targets for the diagnosis and treatment of liver fibrosis". International Journal of Molecular Medicine 36, no. 3 (2015): 747-752. https://doi.org/10.3892/ijmm.2015.2264