Open Access

Evolution of the protease-activated receptor family in vertebrates

  • Authors:
    • Min Jin
    • Hai-Wei Yang
    • Ai-Lin Tao
    • Ji-Fu Wei
  • View Affiliations

  • Published online on: January 22, 2016     https://doi.org/10.3892/ijmm.2016.2464
  • Pages: 593-602
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Belonging to the G protein-coupled receptor (GPcr) family, the protease-activated receptors (Pars) consist of 4 members, Par1-4. Pars mediate the activation of cells via thrombin, serine and other proteases. Such protease-triggered signaling events are thought to be critical for hemostasis, thrombosis and other normal pathological processes. In the present study, we examined the evolution of Pars by analyzing phylogenetic trees, chromosome location, selective pressure and functional divergence based on the 169 functional gene alignment sequences from 57 vertebrate gene sequences. We found that the 4 Pars originated from 4 invertebrate ancestors by phylogenetic trees analysis. The selective pressure results revealed that only Par1 appeared by positive selection during its evolution, while the other PAR members did not. In addition, we noticed that although these Pars evolved separately, the results of functional divergence indicated that their evolutional rates were similar and their functions did not significantly diverge. The findings of our study provide valuable insight into the evolutionary history of the vertebrate Par family.
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March-2016
Volume 37 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Jin M, Yang H, Tao A and Wei J: Evolution of the protease-activated receptor family in vertebrates. Int J Mol Med 37: 593-602, 2016
APA
Jin, M., Yang, H., Tao, A., & Wei, J. (2016). Evolution of the protease-activated receptor family in vertebrates. International Journal of Molecular Medicine, 37, 593-602. https://doi.org/10.3892/ijmm.2016.2464
MLA
Jin, M., Yang, H., Tao, A., Wei, J."Evolution of the protease-activated receptor family in vertebrates". International Journal of Molecular Medicine 37.3 (2016): 593-602.
Chicago
Jin, M., Yang, H., Tao, A., Wei, J."Evolution of the protease-activated receptor family in vertebrates". International Journal of Molecular Medicine 37, no. 3 (2016): 593-602. https://doi.org/10.3892/ijmm.2016.2464