Effects of caffeic acid on learning deficits in a model of Alzheimer's disease

  • Authors:
    • Yunliang Wang
    • Yutong Wang
    • Jinfeng Li
    • Linlin Hua
    • Bing Han
    • Yuzhen Zhang
    • Xiaopeng Yang
    • Zhilei Zeng
    • Hongying Bai
    • Honglei Yin
    • Jiyu Lou
  • View Affiliations

  • Published online on: July 18, 2016     https://doi.org/10.3892/ijmm.2016.2683
  • Pages: 869-875
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Abstract

Caffeic acid is a type of phenolic acid and organic acid. It is found in food (such as tomatoes, carrots, strawberries, blueberries and wheat), beverages (such as wine, tea, coffee and apple juice) as well as Chinese herbal medicines. In the present study, we examined the effects of caffeic acid on learning deficits in a rat model of Alzheimer's disease (AD). The rats were randomly divided into three groups: i) control group, ii) AD model group and iii) caffeic acid group. Caffeic acid significantly rescued learning deficits and increased cognitive function in the rats with AD as demonstrated by the Morris water maze task. Furthermore, caffeic acid administration resulted in a significant decrease in acetylcholinesterase activity and nitrite generation in the rats with AD compared with the AD model group. Furthermore, caffeic acid suppressed oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression and caspase‑3 activity as well as regulating the protein expression of p53 and phosphorylated (p-)p38 MAPK expression in the rats with AD. These experimental results indicate that the beneficial effects of caffeic acid on learning deficits in a model of AD were due to the suppression of oxidative stress and inflammation through the p38 MAPK signaling pathway.
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September-2016
Volume 38 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wang Y, Wang Y, Li J, Hua L, Han B, Zhang Y, Yang X, Zeng Z, Bai H, Yin H, Yin H, et al: Effects of caffeic acid on learning deficits in a model of Alzheimer's disease. Int J Mol Med 38: 869-875, 2016
APA
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y. ... Lou, J. (2016). Effects of caffeic acid on learning deficits in a model of Alzheimer's disease. International Journal of Molecular Medicine, 38, 869-875. https://doi.org/10.3892/ijmm.2016.2683
MLA
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., Lou, J."Effects of caffeic acid on learning deficits in a model of Alzheimer's disease". International Journal of Molecular Medicine 38.3 (2016): 869-875.
Chicago
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., Lou, J."Effects of caffeic acid on learning deficits in a model of Alzheimer's disease". International Journal of Molecular Medicine 38, no. 3 (2016): 869-875. https://doi.org/10.3892/ijmm.2016.2683