Open Access

Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4

  • Authors:
    • Li Yao
    • Yongyan Shi
    • Xinyi Zhao
    • Ana Hou
    • Yujiao Xing
    • Jianhua Fu
    • Xindong Xue
  • View Affiliations

  • Published online on: April 21, 2017     https://doi.org/10.3892/ijmm.2017.2961
  • Pages: 1403-1408
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

With considerable morbidity and mortality, bronchopulmonary dysplasia (BPD) is a focus of attention in neonatology. Hyperoxia-induced lung injury has long been used as a model of BPD. Among all the signaling pathways involved, Toll-like receptor 4 (TLR4) has been demonstrated to play an important role, and is known to be regulated by vitamin D. This study aimed at elucidating the effect of vitamin D on hyperoxia-induced lung injury and the role of TLR4 in the process. Vitamin D was administered to hyperoxia-treated neonatal rats to investigate changes in the morphology of lungs and expression of pro-inflammatory cytokines, apoptotic proteins and TLR4. Vitamin D attenuated hyperoxia-induced lung injury by protecting the integrity of the lung structure, decreasing extracellular matrix deposition and inhibiting inflammation. The upregulation of TLR4 by hyperoxia was ameliorated by vitamin D and apoptosis was reduced. Vitamin D administration antagonized the activation of TLR4 and therefore alleviated inflammation, reduced apoptosis and preserved lung structure.
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June-2017
Volume 39 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yao L, Shi Y, Zhao X, Hou A, Xing Y, Fu J and Xue X: Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4. Int J Mol Med 39: 1403-1408, 2017
APA
Yao, L., Shi, Y., Zhao, X., Hou, A., Xing, Y., Fu, J., & Xue, X. (2017). Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4. International Journal of Molecular Medicine, 39, 1403-1408. https://doi.org/10.3892/ijmm.2017.2961
MLA
Yao, L., Shi, Y., Zhao, X., Hou, A., Xing, Y., Fu, J., Xue, X."Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4". International Journal of Molecular Medicine 39.6 (2017): 1403-1408.
Chicago
Yao, L., Shi, Y., Zhao, X., Hou, A., Xing, Y., Fu, J., Xue, X."Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4". International Journal of Molecular Medicine 39, no. 6 (2017): 1403-1408. https://doi.org/10.3892/ijmm.2017.2961