Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression.

  • Authors:
    • T Okamoto
    • T Kanda
  • View Affiliations

  • Published online on: August 1, 1999     https://doi.org/10.3892/ijmm.4.2.149
  • Pages: 149-201
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Abstract

The administration of concanavalin A (Con A) to mice induces cytokine-dependent hepatitis. In the present study, the effect of glycyrrhizin on Con A-induced hepatitis was examined. Treatment of mice with Con A (0.2 mg/mouse, i.v.) induced elevation of the plasma transaminase activities at 24 h. Mice were treated with glycyrrhizin (100, 200 and 400 mg/kg, i.p.), and glycyrrhizin at the doses of 200 and 400 mg/kg inhibited the Con A-induced elevation of the plasma transaminase activities. At 1 h after Con A treatment, interferon-gamma, tumor necrosis factor-alpha, interleukin-2 and interleukin-6 proteins were released into the plasma. Although treatment with glycyrrhizin at 200 mg/kg inhibited Con A-induced hepatitis, it did not affect the release of any of these Con A-induced cytokines into the plasma. The present results clearly show that glycyrrhizin inhibited Con A-induced hepatitis without affecting cytokine expression.

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Aug 1999
Volume 4 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T and Okamoto T: Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression.. Int J Mol Med 4: 149-201, 1999
APA
Okamoto, T., & Okamoto, T. (1999). Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression.. International Journal of Molecular Medicine, 4, 149-201. https://doi.org/10.3892/ijmm.4.2.149
MLA
Okamoto, T., Kanda, T."Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression.". International Journal of Molecular Medicine 4.2 (1999): 149-201.
Chicago
Okamoto, T., Kanda, T."Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression.". International Journal of Molecular Medicine 4, no. 2 (1999): 149-201. https://doi.org/10.3892/ijmm.4.2.149