Molecular bases for the anti-HIV-1 effect of NO. Commentary.

  • Authors:
    • T Persichini
    • P Ascenzi
    • V Colizzi
    • M Fraziano
    • G Venturini
    • M Colasanti
  • View Affiliations

  • Published online on: October 1, 1999     https://doi.org/10.3892/ijmm.4.4.365
  • Pages: 365-373
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Abstract

In infected human cells, nitric oxide (NO) has been shown to inhibit the replication of the human immunodeficiency virus-1 (HIV-1), the etiological agent of AIDS. Evidence suggests that NO may regulate HIV-1 replication by affecting the sulphydryl redox state. In this respect, it has been very recently demonstrated that NO-donors inactivate the HIV-1-encoded protease and reverse transcriptase in vitro. Further viral and host NO targets may be envisaged. Although no data are available on the anti-HIV-1 effect of NO in vivo, NO-releasing drugs, clinically used in the treatment of cardiovascular disorders, may represent a novel class of molecules for decreasing virus replication. Here, the possible molecular bases for the anti-HIV-1 effect of NO are discussed.

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Oct 1999
Volume 4 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Persichini T, Ascenzi P, Colizzi V, Fraziano M, Venturini G and Colasanti M: Molecular bases for the anti-HIV-1 effect of NO. Commentary.. Int J Mol Med 4: 365-373, 1999
APA
Persichini, T., Ascenzi, P., Colizzi, V., Fraziano, M., Venturini, G., & Colasanti, M. (1999). Molecular bases for the anti-HIV-1 effect of NO. Commentary.. International Journal of Molecular Medicine, 4, 365-373. https://doi.org/10.3892/ijmm.4.4.365
MLA
Persichini, T., Ascenzi, P., Colizzi, V., Fraziano, M., Venturini, G., Colasanti, M."Molecular bases for the anti-HIV-1 effect of NO. Commentary.". International Journal of Molecular Medicine 4.4 (1999): 365-373.
Chicago
Persichini, T., Ascenzi, P., Colizzi, V., Fraziano, M., Venturini, G., Colasanti, M."Molecular bases for the anti-HIV-1 effect of NO. Commentary.". International Journal of Molecular Medicine 4, no. 4 (1999): 365-373. https://doi.org/10.3892/ijmm.4.4.365