Effect of Sorbus commixta on the invasion and migration of human hepatocellular carcinoma Hep3B cells

  • Authors:
    • Hyerin Park
    • Hyunwook Park
    • Tae-Wook Chung
    • Hee‑Jung Choi
    • Yeon-Seop Jung
    • Syng-Ook Lee
    • Ki-Tae Ha
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  • Published online on: June 2, 2017     https://doi.org/10.3892/ijmm.2017.3010
  • Pages: 483-490
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Abstract

Tumor metastasis is a main cause of cancer-related morbidity and mortality. Thus, a number of medicinal herbs and phytochemicals have been investigated as possible candidates for the inhibition of cancer metastasis. Sorbus commixta Hedl. (SC) is a traditional medicinal plant used in the treatment of inflammatory diseases, as it has antioxidant, anti-inflammatory, anti-atherosclerotic and anti-hepatotoxic activities. In this study, we demonstrate that the water extract of SC exerts inhibitory effect on the invasion and migration of hepatocellular carcinoma Hep3B cells. The activity and expression of matrix metalloproteinase (MMP)-9, which is responsible for the invasion of cancer cells, was decreased by SC treatment. The invasive and migratory potentials of the Hep3B cells were also decreased, as evidence by in vitro assay using the Boyden chamber system. In addition, the expression of the chemokine receptors, C-X-C chemokine receptor type 4 (CXCR)4 and C-X-C chemokine receptor type 6 (CXCR6), were inhibited by SC in Hep3B cells. Furthermore, actin fiber organization was markedly suppressed by SC treatment. Taken together, the findings of this study suggest for the first time, to the best of our knowledge, that SC suppresses the invasion and migration of highly metastatic Hep3B cells.
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August-2017
Volume 40 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Park H, Park H, Chung T, Choi HJ, Jung Y, Lee S and Ha K: Effect of Sorbus commixta on the invasion and migration of human hepatocellular carcinoma Hep3B cells. Int J Mol Med 40: 483-490, 2017
APA
Park, H., Park, H., Chung, T., Choi, H., Jung, Y., Lee, S., & Ha, K. (2017). Effect of Sorbus commixta on the invasion and migration of human hepatocellular carcinoma Hep3B cells. International Journal of Molecular Medicine, 40, 483-490. https://doi.org/10.3892/ijmm.2017.3010
MLA
Park, H., Park, H., Chung, T., Choi, H., Jung, Y., Lee, S., Ha, K."Effect of Sorbus commixta on the invasion and migration of human hepatocellular carcinoma Hep3B cells". International Journal of Molecular Medicine 40.2 (2017): 483-490.
Chicago
Park, H., Park, H., Chung, T., Choi, H., Jung, Y., Lee, S., Ha, K."Effect of Sorbus commixta on the invasion and migration of human hepatocellular carcinoma Hep3B cells". International Journal of Molecular Medicine 40, no. 2 (2017): 483-490. https://doi.org/10.3892/ijmm.2017.3010