MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7

  • Authors:
    • Xuanhe Song
    • Yaoping Xie
    • Yang Liu
    • Ming Shao
    • Weiliang Yang
  • View Affiliations

  • Published online on: June 29, 2017     https://doi.org/10.3892/ijmm.2017.3046
  • Pages: 891-897
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Abstract

MicroRNAs (miRNAs or miRs), which are a class of non-coding RNAs, have emerged as effective modulators of various aspects of biological processes. Accumulating evidence has established significant associations between the dysregulation of miRs and tumorigenesis in various types of cancer. However, the role of miR‑492, particularly in osteosarcoma (OS) remains elusive. In present study, we demonstrated that miR‑492 functions as putative tumor suppressor miR in OS. The level of miR‑492 was frequently downregulated in both OS tissues and cell lines. Moreover, the ectopic overexpression of miR‑492 effectively inhibited the proliferation, migration and invasion of OS cell lines. Furthermore, transfection with a miR‑492 overexpression vector also strongly attenuated the growth of xenograft tumors in vivo. p21-activated kinase (PAK7) was identified as the putative target of miR‑492 in OS, and we further found a significantly inverse correlation between PAK7 and miR‑492 in OS specimens. Taken together, our study has unraveled a novel role for miR‑492 in OS and may help in establishing the rationale for more effective treatment strategies for OS via miR regulation.
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September-2017
Volume 40 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Song X, Xie Y, Liu Y, Shao M and Yang W: MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7. Int J Mol Med 40: 891-897, 2017
APA
Song, X., Xie, Y., Liu, Y., Shao, M., & Yang, W. (2017). MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7. International Journal of Molecular Medicine, 40, 891-897. https://doi.org/10.3892/ijmm.2017.3046
MLA
Song, X., Xie, Y., Liu, Y., Shao, M., Yang, W."MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7". International Journal of Molecular Medicine 40.3 (2017): 891-897.
Chicago
Song, X., Xie, Y., Liu, Y., Shao, M., Yang, W."MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7". International Journal of Molecular Medicine 40, no. 3 (2017): 891-897. https://doi.org/10.3892/ijmm.2017.3046