Histone lysine methylation and congenital heart disease: From bench to bedside (Review)

  • Authors:
    • Xin Yi
    • Xuejun Jiang
    • Xiaoyan Li
    • Ding-Sheng Jiang
  • View Affiliations

  • Published online on: August 30, 2017     https://doi.org/10.3892/ijmm.2017.3115
  • Pages: 953-964
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Abstract

Histone post-translational modifications (PTM) as one of the key epigenetic regulatory mechanisms that plays critical role in various biological processes, including regulating chromatin structure dynamics and gene expression. Histone lysine methyltransferase contributes to the establishment and maintenance of differential histone methylation status, which can recognize histone methylated sites and build an association between these modifications and their downstream processes. Recently, it was found that abnormalities in the histone lysine methylation level or pattern may lead to the occurrence of many types of cardiovascular diseases, such as congenital heart disease (CHD). In order to provide new theoretical basis and targets for the treatment of CHD from the view of developmental biology and genetics, this review discusses and elaborates on the association between histone lysine methylation modifications and CHD.
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October-2017
Volume 40 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Yi X, Jiang X, Li X and Jiang D: Histone lysine methylation and congenital heart disease: From bench to bedside (Review). Int J Mol Med 40: 953-964, 2017
APA
Yi, X., Jiang, X., Li, X., & Jiang, D. (2017). Histone lysine methylation and congenital heart disease: From bench to bedside (Review). International Journal of Molecular Medicine, 40, 953-964. https://doi.org/10.3892/ijmm.2017.3115
MLA
Yi, X., Jiang, X., Li, X., Jiang, D."Histone lysine methylation and congenital heart disease: From bench to bedside (Review)". International Journal of Molecular Medicine 40.4 (2017): 953-964.
Chicago
Yi, X., Jiang, X., Li, X., Jiang, D."Histone lysine methylation and congenital heart disease: From bench to bedside (Review)". International Journal of Molecular Medicine 40, no. 4 (2017): 953-964. https://doi.org/10.3892/ijmm.2017.3115