Open Access

miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells

  • Authors:
    • Fei Zhu
    • Qiong Wu
    • Zhen Ni
    • Chao Lei
    • Ting Li
    • Yongquan Shi
  • View Affiliations

  • Published online on: March 22, 2018     https://doi.org/10.3892/ijmm.2018.3581
  • Pages: 228-236
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite the improvement in gastric cancer (GC) treatment, multidrug resistance (MDR) is still a significant reason for chemotherapy failure. Our previous studies have demonstrated that miR-19a/b upregulation directly promoted MDR in GC cells. However, the exact regulation and the potential molecule mechanisms have not been fully clarified. In this study, we found that miR-19a/b was directly involved in 5-aza-2'-deoxycytidine (5-Aza-dC) induced MDR of GC cells. Mechanically, demethylation of miR-19a/b repressed methyl CpG binding protein 2 (MeCP2) expression via direct binding at the 3'-untranslated regions, which then alleviated the inhibitory effects of MeCP2 on miR-19a/b expression. Thus, the mutual regulatory network sustains preservation of the expression levels of miR-19a/b. We further demonstrated that miR-19a/b expression was inversely correlated to MeCP2 expression in GC tissues. These data showed an intimate interplay among miR-19a/b methylation, MeCP2 activity, and MDR, revealing a potential therapeutic target for GC.
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July-2018
Volume 42 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhu F, Wu Q, Ni Z, Lei C, Li T and Shi Y: miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells. Int J Mol Med 42: 228-236, 2018
APA
Zhu, F., Wu, Q., Ni, Z., Lei, C., Li, T., & Shi, Y. (2018). miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells. International Journal of Molecular Medicine, 42, 228-236. https://doi.org/10.3892/ijmm.2018.3581
MLA
Zhu, F., Wu, Q., Ni, Z., Lei, C., Li, T., Shi, Y."miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells". International Journal of Molecular Medicine 42.1 (2018): 228-236.
Chicago
Zhu, F., Wu, Q., Ni, Z., Lei, C., Li, T., Shi, Y."miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells". International Journal of Molecular Medicine 42, no. 1 (2018): 228-236. https://doi.org/10.3892/ijmm.2018.3581