Open Access

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

  • Authors:
    • Xueqing Zou
    • Yongmei Wang
    • Cheng Peng
    • Ben Wang
    • Zhengchuan Niu
    • Zequn Li
    • Jun Niu
  • View Affiliations

  • Published online on: July 19, 2018     https://doi.org/10.3892/ijmm.2018.3787
  • Pages: 2020-2030
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxaliplatin is a core chemotherapeutic agent used for the treatment of colorectal liver metastasis; however, liver injury caused by oxaliplatin increases the risk of peri‑operative morbidity and mortality. Magnesium isoglycyrrhizinate (MgiG) is a magnesium salt of 18‑α glycyrrhizic acid stereoisomer that has demonstrated liver‑protective effects against toxins and hepatitis. In the present study, the liver‑protective effect of MgiG against oxaliplatin‑induced hepatic injury was examined in vitro and in vivo. The results demonstrated that MgiG had a protective effect against oxaliplatin‑induced liver injury, as evidenced by the alleviation of hepatic pathological damage and transaminase levels. The protective effect of MgiG was demonstrated to be correlated with inhibition of oxidative stress, the interleukin‑6 pathway and the coagulation system. Altogether, the present findings suggested that MgiG may have potential value in the clinical prevention and treatment of oxaliplatin‑induced liver injury.
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October-2018
Volume 42 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zou X, Wang Y, Peng C, Wang B, Niu Z, Li Z and Niu J: Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury. Int J Mol Med 42: 2020-2030, 2018
APA
Zou, X., Wang, Y., Peng, C., Wang, B., Niu, Z., Li, Z., & Niu, J. (2018). Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury. International Journal of Molecular Medicine, 42, 2020-2030. https://doi.org/10.3892/ijmm.2018.3787
MLA
Zou, X., Wang, Y., Peng, C., Wang, B., Niu, Z., Li, Z., Niu, J."Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury". International Journal of Molecular Medicine 42.4 (2018): 2020-2030.
Chicago
Zou, X., Wang, Y., Peng, C., Wang, B., Niu, Z., Li, Z., Niu, J."Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury". International Journal of Molecular Medicine 42, no. 4 (2018): 2020-2030. https://doi.org/10.3892/ijmm.2018.3787