Open Access

An impaired hepatic clock system effects lipid metabolism in rats with nephropathy

  • Authors:
    • Peipei Chen
    • Ruiyu Zhang
    • Lijun Mou
    • Xuewang Li
    • Yan Qin
    • Xuemei Li
  • View Affiliations

  • Published online on: August 22, 2018     https://doi.org/10.3892/ijmm.2018.3833
  • Pages: 2720-2736
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hyperlipidemia is a key clinical feature in patients with nephrotic syndrome (NS) that is associated with the incidence of cardiovascular events. Recent studies have suggested that the disorders of triglycerides, gluconeogenesis and liver glucose metabolism are associated with the abnormal transcription of clock genes. However, changes to the circadian rhythm of blood lipids in NS require further exploration, and the effects of NS on the hepatic clock system remain to be elucidated. In the present study, the impaired diurnal rhythm of the hepatic core clock genes (BMAL1, CLOCK, CRY1, CRY2, PER1 and PER2) significantly induced circadian rhythm abnormalities in liver‑specific clock‑controlled genes (LXR, CYP7A1, SREBP‑1, ABCA1, DEC1 and DEC2; all P<0.05), which were significantly associated with the abnormal diurnal rhythms of triglyceride, total cholesterol, aspartate aminotransferase and alanine aminotransferase (all P<0.05) in rats with Adriamycin‑induced nephropathy. Furthermore, a protein‑protein interaction network was identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses based on the human database was conducted to obtain signaling pathway and correlation prediction analyses of overall human clock and clock‑controlled gene correlations. Strong correlations of the aforementioned clock genes were detected (avg. local clustering coefficient, 0.849) which suggested significant enrichment in circadian rhythm signaling. The present results indicated that damage to hepatic clock systems may impact blood lipid circadian rhythm disorders in NS, and offer a starting point for understanding the crosstalk between peripheral organs and peripheral clock systems.
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November-2018
Volume 42 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Chen P, Zhang R, Mou L, Li X, Qin Y and Li X: An impaired hepatic clock system effects lipid metabolism in rats with nephropathy. Int J Mol Med 42: 2720-2736, 2018
APA
Chen, P., Zhang, R., Mou, L., Li, X., Qin, Y., & Li, X. (2018). An impaired hepatic clock system effects lipid metabolism in rats with nephropathy. International Journal of Molecular Medicine, 42, 2720-2736. https://doi.org/10.3892/ijmm.2018.3833
MLA
Chen, P., Zhang, R., Mou, L., Li, X., Qin, Y., Li, X."An impaired hepatic clock system effects lipid metabolism in rats with nephropathy". International Journal of Molecular Medicine 42.5 (2018): 2720-2736.
Chicago
Chen, P., Zhang, R., Mou, L., Li, X., Qin, Y., Li, X."An impaired hepatic clock system effects lipid metabolism in rats with nephropathy". International Journal of Molecular Medicine 42, no. 5 (2018): 2720-2736. https://doi.org/10.3892/ijmm.2018.3833