Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).

  • Authors:
    • E Minet
    • G Michel
    • J Remacle
    • C Michiels
  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/ijmm.5.3.253
  • Pages: 253-262
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Abstract

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor first identified as being activated by hypoxia but also in normoxic conditions by insulin and IGF-2. It is able to induce the expression of glycolytic genes and hence the ATP production, it also regulates the expression of the angiogenic factor VEGF and stimulates erythropoiesis via EPO production. HIF-1 is a protein necessary for the normal embryonic and cardiovascular system development, but seems to be also involved in cancer progression and apoptosis. Thus, it appears that HIF-1 plays a central role in normal cellular functions and in tissue metabolism but it is also involved in pathological evolutions raising its interest as a therapeutic target. In this review, we summarize the dual role of HIF-1 as a major component of the embryo development, as well as an element of tumor progression and of anoxia-induced apoptosis.

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Mar 2000
Volume 5 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Minet E, Michel G, Remacle J and Michiels C: Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).. Int J Mol Med 5: 253-262, 2000
APA
Minet, E., Michel, G., Remacle, J., & Michiels, C. (2000). Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).. International Journal of Molecular Medicine, 5, 253-262. https://doi.org/10.3892/ijmm.5.3.253
MLA
Minet, E., Michel, G., Remacle, J., Michiels, C."Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).". International Journal of Molecular Medicine 5.3 (2000): 253-262.
Chicago
Minet, E., Michel, G., Remacle, J., Michiels, C."Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).". International Journal of Molecular Medicine 5, no. 3 (2000): 253-262. https://doi.org/10.3892/ijmm.5.3.253