Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME).

  • Authors:
    • E Kirsten
    • E Kun
  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/ijmm.5.3.279
  • Pages: 279-360
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Abstract

The cellular pharmacologic actions, as measured by cell killing, of INH2BP, DIME and INO2BA (+ BSO) were determined in three types of cancer cells and compared to their action on quiescent confluent human foreskin fibroblast (HSF) and pre-confluent growing fibroblasts. The confluent HSF cells were completely refractory to the action of INH2BP and DIME, but were killed by INO2BA (+ BSO). Proliferating HSF and all three tumor cell types were killed by all three drugs. The apparent in vivo tumor specificity of INH2BP and DIME is explained by preferential cell cycle dependent selective drug uptake into tumor cells and by drug metabolism that reverses drug action in less vigorously cycling normal cells. The covalent binding of iodonitrosobenzamide (formed from INO2BA) and its toxicity are regulated by the concentration of GSH, and exhibit no cell cycle selectivity.

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Mar 2000
Volume 5 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kirsten E and Kirsten E: Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME).. Int J Mol Med 5: 279-360, 2000
APA
Kirsten, E., & Kirsten, E. (2000). Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME).. International Journal of Molecular Medicine, 5, 279-360. https://doi.org/10.3892/ijmm.5.3.279
MLA
Kirsten, E., Kun, E."Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME).". International Journal of Molecular Medicine 5.3 (2000): 279-360.
Chicago
Kirsten, E., Kun, E."Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME).". International Journal of Molecular Medicine 5, no. 3 (2000): 279-360. https://doi.org/10.3892/ijmm.5.3.279