Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by trovafloxacin.

  • Authors:
    • S Gollapudi
    • S Gupta
    • H Thadepalli
  • View Affiliations

  • Published online on: June 1, 2000     https://doi.org/10.3892/ijmm.5.6.615
  • Pages: 615-623
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Abstract

We have previously reported that virulent Salmonella typhimurium induces replication of latent HIV-1 in U1 cells, via activation of tumor necrosis factor-alpha (TNF-alpha) production. In the present study, we show that Trovafloxacin, a new quinolone antibiotic, inhibits S. typhimurium-induced TNF-alpha production and HIV-1 replication. In addition, Trovafloxacin inhibits TNF-alpha-induced reactivation of latent HIV-1 in U1 cells. The concentrations of Trovafloxacin that inhibited HIV-1 replication are comparable to the plasma and tissue levels achieved by therapeutic dosage used in the treatment of bacterial infections. Therefore, Trovafloxacin is a potential candidate for adjunct therapy in HIV-1 infection.

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Jun 2000
Volume 5 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Gollapudi S, Gupta S and Thadepalli H: Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by trovafloxacin.. Int J Mol Med 5: 615-623, 2000
APA
Gollapudi, S., Gupta, S., & Thadepalli, H. (2000). Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by trovafloxacin.. International Journal of Molecular Medicine, 5, 615-623. https://doi.org/10.3892/ijmm.5.6.615
MLA
Gollapudi, S., Gupta, S., Thadepalli, H."Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by trovafloxacin.". International Journal of Molecular Medicine 5.6 (2000): 615-623.
Chicago
Gollapudi, S., Gupta, S., Thadepalli, H."Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by trovafloxacin.". International Journal of Molecular Medicine 5, no. 6 (2000): 615-623. https://doi.org/10.3892/ijmm.5.6.615