Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.

  • Authors:
    • J A Garcia-Martinez
    • J Cancelas
    • M L Villanueva-Peñacarrillo
    • I Valverde
    • W J Malaisse
  • View Affiliations

  • Published online on: September 1, 2000     https://doi.org/10.3892/ijmm.6.3.319
  • Pages: 319-340
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Abstract

Adult rats, that had been injected with streptozotocin during the neonatal period, received a primed constant infusion of succinic acid dimethyl ester (SAD; 0.5 micromol followed by 0.25 micromol x min(-1), both per g body wt.) in saline for 15 min and, at the 5th min of such an infusion, an intravenous injection of GLP-1 (5 pmol per g body wt.). Within 2 min, the ester increased the plasma insulin concentration by 0.33+/-0.05 nM. Likewise, within 2 min, GLP-1 provoked a marked increase in plasma insulin concentration; such an increase was comparable in rats infused with either saline or SAD, with an overall mean value of 0.93+/-0.07 nM. In the rats infused with SAD, however, the secretory response to GLP-1 appeared more sustained than in the saline-infused animals. For instance, the paired ratio for the insulinogenic index at 10/2 min after GLP-1 injection averaged 30.5+/-4.0% in SAD-infused rats, as compared (P<0.025) to only 17.0+/-2.5% in saline-infused animals. These findings suggest that succinic acid esters could be used to prolong the insulinotropic action of GLP-1 in the treatment of type-2 diabetes.

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Sep 2000
Volume 6 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Garcia-Martinez J, Cancelas J, Villanueva-Peñacarrillo M, Valverde I and Malaisse W: Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.. Int J Mol Med 6: 319-340, 2000
APA
Garcia-Martinez, J., Cancelas, J., Villanueva-Peñacarrillo, M., Valverde, I., & Malaisse, W. (2000). Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.. International Journal of Molecular Medicine, 6, 319-340. https://doi.org/10.3892/ijmm.6.3.319
MLA
Garcia-Martinez, J., Cancelas, J., Villanueva-Peñacarrillo, M., Valverde, I., Malaisse, W."Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.". International Journal of Molecular Medicine 6.3 (2000): 319-340.
Chicago
Garcia-Martinez, J., Cancelas, J., Villanueva-Peñacarrillo, M., Valverde, I., Malaisse, W."Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.". International Journal of Molecular Medicine 6, no. 3 (2000): 319-340. https://doi.org/10.3892/ijmm.6.3.319