Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.

  • Authors:
    • J H Lee
    • W S Ko
    • Y H Kim
    • H S Kang
    • H D Kim
    • B T Choi
  • View Affiliations

  • Published online on: January 1, 2001     https://doi.org/10.3892/ijmm.7.1.79
  • Pages: 79-162
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We investigated the anti-inflammatory effects of aqueous extract from Lonicera japonica flower (AELJ), a traditional skin rash drug, in lipopolysaccharide (LPS)-induced rat liver sepsis. Immunoblot analysis showed that the level of nuclear factor (NF)-kappaBp65 was rapidly up-regulated and inhibitory (I)-kappaBalpha was down-regulated by LPS challenge. However, AELJ inhibited the increase of NF-kappaBp65 and degradation of I-kappaBalpha in the liver of LPS-challenged rats. Immunohistochemical analysis of rat hepatocytes showed that LPS-induced inflammatory responses, involving degradation of I-kappaBalpha and induction of NF-kappaBp65, tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS), are partially inhibited by pretreatment with AELJ. These results suggest that AELJ may act as a therapeutic agent for inflammatory disease through a selective regulation of NF-kappaB activation.

Related Articles

Journal Cover

January 2001
Volume 7 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lee J, Ko W, Kim Y, Kang H, Kim H and Choi B: Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.. Int J Mol Med 7: 79-162, 2001
APA
Lee, J., Ko, W., Kim, Y., Kang, H., Kim, H., & Choi, B. (2001). Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.. International Journal of Molecular Medicine, 7, 79-162. https://doi.org/10.3892/ijmm.7.1.79
MLA
Lee, J., Ko, W., Kim, Y., Kang, H., Kim, H., Choi, B."Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.". International Journal of Molecular Medicine 7.1 (2001): 79-162.
Chicago
Lee, J., Ko, W., Kim, Y., Kang, H., Kim, H., Choi, B."Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.". International Journal of Molecular Medicine 7, no. 1 (2001): 79-162. https://doi.org/10.3892/ijmm.7.1.79