Pancreatic glycogen content in Goto-Kakizaki rats

  • Authors:
    • L. Ladriere
    • W. J. Malaisse
  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijmm.7.2.173
  • Pages: 173-175
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Abstract

In situations of sustained hyperglycemia, much larger amounts of glycogen accumulate in islet B-cells than in other pancreatic cells. The labelling of such a glycogen pool could thus conceivably provide a mean for assessing the relative contribution of insulin-producing cells to the total pancreatic mass. In such a perspective, the present study aims at investigating pancreatic glycogen accumulation in hereditarily diabetic Goto-Kakizaki (GK) rats. When cultured at 30 mM D-glucose in the presence of D-[U-14C]glucose, pancreatic islets from GK rats accumulated 14C-labelled glycogen in a manner comparable to that previously documented in islets from normal rats. Likewise, the glycogen content of the pancreatic gland, relative to the plasma D-glucose concentration, was not different in GK and normal rats. The GK rats thus apparently represent a suitable model for further studies on the in vivo labelling of B-cell glycogen in the perspective of the non-invasive imaging and quantification of the endocrine pancreas.

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February 2001
Volume 7 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ladriere L and Ladriere L: Pancreatic glycogen content in Goto-Kakizaki rats. Int J Mol Med 7: 173-175, 2001
APA
Ladriere, L., & Ladriere, L. (2001). Pancreatic glycogen content in Goto-Kakizaki rats. International Journal of Molecular Medicine, 7, 173-175. https://doi.org/10.3892/ijmm.7.2.173
MLA
Ladriere, L., Malaisse, W. J."Pancreatic glycogen content in Goto-Kakizaki rats". International Journal of Molecular Medicine 7.2 (2001): 173-175.
Chicago
Ladriere, L., Malaisse, W. J."Pancreatic glycogen content in Goto-Kakizaki rats". International Journal of Molecular Medicine 7, no. 2 (2001): 173-175. https://doi.org/10.3892/ijmm.7.2.173