Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue

  • Authors:
    • Wei Zhu
    • Thomas V. Bilfinger
    • Geert Baggerman
    • Yannick Goumon
    • George B. Stefano
  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijmm.7.4.419
  • Pages: 419-422
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Human atria contain the opiate alkaloids morphine and morphine 6 glucuronide as determined by high performance liquid chromatography coupled to electrochemical detection. This method found endogenous morphine and morphine 6 glucuronide at 106.28±61.58 and 48.32±24.63 (± SD) ng/gm wet weight, respectively. Identification of these opiates was confirmed by nano electrospray ionization double quadrupole orthogonal acceleration time of flight mass spectrometry. Furthermore, human saphenous vein fragments did not contain morphine as determined by these methods. Fragmentation from a selected precursor ion by collision-induced dissociation of endogenous morphine 6 glucuronide (462.14 da) yields morphine (286.14 Da) obtained from the heart tissues and with the authentic material, further demonstrating the presence of endogenous morphine. Thus, vascular tissues appear to contain endogenous opiate alkaloids.

Related Articles

Journal Cover

April 2001
Volume 7 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhu W, Bilfinger TV, Baggerman G, Goumon Y and Stefano GB: Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue. Int J Mol Med 7: 419-422, 2001
APA
Zhu, W., Bilfinger, T.V., Baggerman, G., Goumon, Y., & Stefano, G.B. (2001). Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue. International Journal of Molecular Medicine, 7, 419-422. https://doi.org/10.3892/ijmm.7.4.419
MLA
Zhu, W., Bilfinger, T. V., Baggerman, G., Goumon, Y., Stefano, G. B."Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue". International Journal of Molecular Medicine 7.4 (2001): 419-422.
Chicago
Zhu, W., Bilfinger, T. V., Baggerman, G., Goumon, Y., Stefano, G. B."Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue". International Journal of Molecular Medicine 7, no. 4 (2001): 419-422. https://doi.org/10.3892/ijmm.7.4.419