Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas

  • Authors:
    • Minoru Tomizawa
    • Yan-Qing Wang
    • Masaaki Ebara
    • Hiromitsu Saisho
    • Kazuo Watanabe
    • Akira Nakagawara
    • Masatoshi Tagawa
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijmm.9.6.597
  • Pages: 597-600
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Abstract

CCAAT/enhancer binding protein α (C/EBPα), expressed at a high level in liver, plays an important role in proliferation and differentiation of hepatocytes. Previous studies showed that an expression level of the C/EBPα gene in hepatocytes was downregulated in response to proliferation signals and that forced expression of the C/EBPα gene in a number of cells caused cell cycle arrest. We compared the expression level of the C/EBPα gene in surgical specimens between hepatocellular carcinoma and non-tumorous regions of the same patients. In 9 out of 13 cases, the expression level in the tumors was decreased compared with that in corresponding non-tumorous regions. Transfection of the C/EBPα gene into C/EBPα-negative human hepatocellular carcinoma HLF cells, however, did not influence the rate of cell proliferation or cell cycle. Our present data suggest that the expression of the C/EBPα gene was downregulated in the majority of human hepatocellular carcinoma but the expression may not be directly associated with impaired proliferative activity of hepatocellular carcinoma cells.

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June 2002
Volume 9 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tomizawa M, Wang Y, Ebara M, Saisho H, Watanabe K, Nakagawara A and Tagawa M: Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas. Int J Mol Med 9: 597-600, 2002
APA
Tomizawa, M., Wang, Y., Ebara, M., Saisho, H., Watanabe, K., Nakagawara, A., & Tagawa, M. (2002). Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas. International Journal of Molecular Medicine, 9, 597-600. https://doi.org/10.3892/ijmm.9.6.597
MLA
Tomizawa, M., Wang, Y., Ebara, M., Saisho, H., Watanabe, K., Nakagawara, A., Tagawa, M."Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas". International Journal of Molecular Medicine 9.6 (2002): 597-600.
Chicago
Tomizawa, M., Wang, Y., Ebara, M., Saisho, H., Watanabe, K., Nakagawara, A., Tagawa, M."Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas". International Journal of Molecular Medicine 9, no. 6 (2002): 597-600. https://doi.org/10.3892/ijmm.9.6.597