RAS P21 EXPRESSION IN NEUROBLASTOMAS AND GANGLIO-NEUROBLASTOMAS - CORRELATION WITH PATIENTS PROGNOSIS

  • Authors:
    • DA SPANDIDOS
    • D ARVANITIS
    • JK FIELD
  • View Affiliations

  • Published online on: June 1, 1992     https://doi.org/10.3892/ijo.1.1.53
  • Pages: 53-58
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ras p21 expression was investigated in 28 cases of neuroblastomas and 12 cases of ganglio-neuroblastomas by the biotin-streptavidin immunoperoxidase method using the anti-ras p21 rat monoclonal antibody Y13-259. The results showed that 28% of neuroblastomas and 92% of ganglio-neuroblastomas demonstrated elevated ras p21 expression. However, in this series of patients 10 of 12 ganglio-neuroblastomas were staged as early disease (stage I or II) compared to 15 of 28 neuroblastomas, with similar staged disease. On analysing all of these tumours into early and late disease (i.e. stage I and II; and stage III and IV) a correlation was found between p21-ras overexpression and early disease (P<0.0001). As staging of neuroblastomas has been considered to be a prognostic indicator, it is argued that ras p21 over-expression maybe an indicator for a favourable prognosis in these patients.

Related Articles

Journal Cover

June 1992
Volume 1 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
SPANDIDOS D, ARVANITIS D and FIELD J: RAS P21 EXPRESSION IN NEUROBLASTOMAS AND GANGLIO-NEUROBLASTOMAS - CORRELATION WITH PATIENTS PROGNOSIS. Int J Oncol 1: 53-58, 1992
APA
SPANDIDOS, D., ARVANITIS, D., & FIELD, J. (1992). RAS P21 EXPRESSION IN NEUROBLASTOMAS AND GANGLIO-NEUROBLASTOMAS - CORRELATION WITH PATIENTS PROGNOSIS. International Journal of Oncology, 1, 53-58. https://doi.org/10.3892/ijo.1.1.53
MLA
SPANDIDOS, D., ARVANITIS, D., FIELD, J."RAS P21 EXPRESSION IN NEUROBLASTOMAS AND GANGLIO-NEUROBLASTOMAS - CORRELATION WITH PATIENTS PROGNOSIS". International Journal of Oncology 1.1 (1992): 53-58.
Chicago
SPANDIDOS, D., ARVANITIS, D., FIELD, J."RAS P21 EXPRESSION IN NEUROBLASTOMAS AND GANGLIO-NEUROBLASTOMAS - CORRELATION WITH PATIENTS PROGNOSIS". International Journal of Oncology 1, no. 1 (1992): 53-58. https://doi.org/10.3892/ijo.1.1.53