CIRCUMVENTION OF CISPLATIN RESISTANCE IN H-RAS TRANSFORMED-NIH/3T3 CELLS BY SUPPRESSOR MUTANT OF H-RAS

  • Authors:
    • N SHINOHARA
    • Y OGISO
    • N KUZUMAKI
    • L MULLAUER
    • M KATABAMI
    • M TOGASHI
    • T KOYANAGI
  • View Affiliations

  • Published online on: June 1, 1992     https://doi.org/10.3892/ijo.1.1.93
  • Pages: 93-96
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Abstract

The expression of H-ras oncogene, it has been shown, induces cisplatin resistance in vitro. Using two types of flat revertants (R1, F32/F33) which lost the transformed phenotypes, we studied the mechanism of the cisplatin resistance. R1 cells, which expressed an activated c-H-ras oncogene, exhibited increased cisplatin resistance. Further, F32/F33 cell lines, which were suppressed the H-ras function by a suppressor mutant of H-ras, restored the cisplatin sensitivity. These results implicate that the cisplatin resistance was directly related to the expression of H-ras and can be circumvented by suppression of the H-ras functions.

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June 1992
Volume 1 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
SHINOHARA N, OGISO Y, KUZUMAKI N, MULLAUER L, KATABAMI M, TOGASHI M and KOYANAGI T: CIRCUMVENTION OF CISPLATIN RESISTANCE IN H-RAS TRANSFORMED-NIH/3T3 CELLS BY SUPPRESSOR MUTANT OF H-RAS. Int J Oncol 1: 93-96, 1992
APA
SHINOHARA, N., OGISO, Y., KUZUMAKI, N., MULLAUER, L., KATABAMI, M., TOGASHI, M., & KOYANAGI, T. (1992). CIRCUMVENTION OF CISPLATIN RESISTANCE IN H-RAS TRANSFORMED-NIH/3T3 CELLS BY SUPPRESSOR MUTANT OF H-RAS. International Journal of Oncology, 1, 93-96. https://doi.org/10.3892/ijo.1.1.93
MLA
SHINOHARA, N., OGISO, Y., KUZUMAKI, N., MULLAUER, L., KATABAMI, M., TOGASHI, M., KOYANAGI, T."CIRCUMVENTION OF CISPLATIN RESISTANCE IN H-RAS TRANSFORMED-NIH/3T3 CELLS BY SUPPRESSOR MUTANT OF H-RAS". International Journal of Oncology 1.1 (1992): 93-96.
Chicago
SHINOHARA, N., OGISO, Y., KUZUMAKI, N., MULLAUER, L., KATABAMI, M., TOGASHI, M., KOYANAGI, T."CIRCUMVENTION OF CISPLATIN RESISTANCE IN H-RAS TRANSFORMED-NIH/3T3 CELLS BY SUPPRESSOR MUTANT OF H-RAS". International Journal of Oncology 1, no. 1 (1992): 93-96. https://doi.org/10.3892/ijo.1.1.93