N1-SUBSTITUTED TETRA-BENZAMIDINES - INHIBITION OF DNA-PROTEIN INTERACTIONS AND INVITRO TUMOR-CELL GROWTH

  • Authors:
    • G FERIOTTO
    • C NASTRUZZI
    • C MISCHIATI
    • R GAMBARI
  • View Affiliations

  • Published online on: August 1, 1992     https://doi.org/10.3892/ijo.1.3.277
  • Pages: 277-281
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Abstract

The pharmacological-mediated inhibition of the interaction between regulatory proteins and target DNA sequences could represent a potential experimental strategy to control growth of neoplastic cells, viral DNA replication and biological life cycle of infectious microorganisms. Aromatic polyamidines are powerful inhibitors of DNA-protein interactions, in vitro proliferation of tumor cell lines and in vivo growth of tumorigenic cells xenografted into nude mice. In order to obtain more detailed information on structure-activity relationships, we have analysed the effects of different aromatic polyamidines on the binding of a recombinant protein, the Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA-1) to the DNA target sequence of EBV, containing the 12 bp palindromic consensus TAGCATATGCTA sequence. The results obtained suggest that aromatic polyamidines differentially inhibit the interactions between DNA-binding proteins and target DNA sequences, leading to differential effects on tumor cell growth.

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August 1992
Volume 1 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
FERIOTTO G, NASTRUZZI C, MISCHIATI C and GAMBARI R: N1-SUBSTITUTED TETRA-BENZAMIDINES - INHIBITION OF DNA-PROTEIN INTERACTIONS AND INVITRO TUMOR-CELL GROWTH. Int J Oncol 1: 277-281, 1992
APA
FERIOTTO, G., NASTRUZZI, C., MISCHIATI, C., & GAMBARI, R. (1992). N1-SUBSTITUTED TETRA-BENZAMIDINES - INHIBITION OF DNA-PROTEIN INTERACTIONS AND INVITRO TUMOR-CELL GROWTH. International Journal of Oncology, 1, 277-281. https://doi.org/10.3892/ijo.1.3.277
MLA
FERIOTTO, G., NASTRUZZI, C., MISCHIATI, C., GAMBARI, R."N1-SUBSTITUTED TETRA-BENZAMIDINES - INHIBITION OF DNA-PROTEIN INTERACTIONS AND INVITRO TUMOR-CELL GROWTH". International Journal of Oncology 1.3 (1992): 277-281.
Chicago
FERIOTTO, G., NASTRUZZI, C., MISCHIATI, C., GAMBARI, R."N1-SUBSTITUTED TETRA-BENZAMIDINES - INHIBITION OF DNA-PROTEIN INTERACTIONS AND INVITRO TUMOR-CELL GROWTH". International Journal of Oncology 1, no. 3 (1992): 277-281. https://doi.org/10.3892/ijo.1.3.277