A CIRCULATING HEAT-RESISTANT MUCIN-LIKE ANTIGEN IN PATIENTS WITH LUNG-CANCER DETECTED BY A NEW MURINE MONOCLONAL-ANTIBODY

  • Authors:
    • N KOHNO
    • M MIYAKE
    • Y INOUE
    • A YOKOYAMA
    • K HIWADA
    • M TANABE
    • M YAMAKIDO
    • S KYOIZUMI
    • M AKIYAMA
  • View Affiliations

  • Published online on: November 1, 1992     https://doi.org/10.3892/ijo.1.6.649
  • Pages: 649-655
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Abstract

We discovered a circulating mucin-like antigen designated as CAM-14 detected by a new murine monoclonal antibody KL-14 (IgM). We found different heat resistant properties between serum CAM- 14 from normal individuals and from lung cancer patients. Heat treatment had less effect on the levels of CAM-14 in sera from lung cancer patients, whereas CAM-14 levels in sera from normal individuals were markedly decreased after heat treatment at tempratures > 65-degrees-C. As a serum tumor marker, CAM- 14 had only very low levels of false-positive values with a high specificity and effectively increased the positive rate for lung cancer patients when used together with carcinoembryonic antigen.

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November 1992
Volume 1 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
KOHNO N, MIYAKE M, INOUE Y, YOKOYAMA A, HIWADA K, TANABE M, YAMAKIDO M, KYOIZUMI S and AKIYAMA M: A CIRCULATING HEAT-RESISTANT MUCIN-LIKE ANTIGEN IN PATIENTS WITH LUNG-CANCER DETECTED BY A NEW MURINE MONOCLONAL-ANTIBODY. Int J Oncol 1: 649-655, 1992
APA
KOHNO, N., MIYAKE, M., INOUE, Y., YOKOYAMA, A., HIWADA, K., TANABE, M. ... AKIYAMA, M. (1992). A CIRCULATING HEAT-RESISTANT MUCIN-LIKE ANTIGEN IN PATIENTS WITH LUNG-CANCER DETECTED BY A NEW MURINE MONOCLONAL-ANTIBODY. International Journal of Oncology, 1, 649-655. https://doi.org/10.3892/ijo.1.6.649
MLA
KOHNO, N., MIYAKE, M., INOUE, Y., YOKOYAMA, A., HIWADA, K., TANABE, M., YAMAKIDO, M., KYOIZUMI, S., AKIYAMA, M."A CIRCULATING HEAT-RESISTANT MUCIN-LIKE ANTIGEN IN PATIENTS WITH LUNG-CANCER DETECTED BY A NEW MURINE MONOCLONAL-ANTIBODY". International Journal of Oncology 1.6 (1992): 649-655.
Chicago
KOHNO, N., MIYAKE, M., INOUE, Y., YOKOYAMA, A., HIWADA, K., TANABE, M., YAMAKIDO, M., KYOIZUMI, S., AKIYAMA, M."A CIRCULATING HEAT-RESISTANT MUCIN-LIKE ANTIGEN IN PATIENTS WITH LUNG-CANCER DETECTED BY A NEW MURINE MONOCLONAL-ANTIBODY". International Journal of Oncology 1, no. 6 (1992): 649-655. https://doi.org/10.3892/ijo.1.6.649