NEOPLASTIC RESPONSE TO DMBA POWDER IN MAMMARY AND INTERSCAPULAR TISSUES IN WISTAR FURTH AND COPENHAGEN FEMALE RATS

  • Authors:
    • H TAKAHASHI
    • T SHOJI
    • A TSUBURA
    • S MORII
  • View Affiliations

  • Published online on: November 1, 1992     https://doi.org/10.3892/ijo.1.6.657
  • Pages: 657-659
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Abstract

To investigate genetic factors in local tumorigenesis, a dusting of 1 mg of 7,12-dimethylbenz(a)-anthracene (DMBA) powder was directly applied to exposed mammary tissue in 15 Wistar/Furth (WF), 20 Copenhagen (Cop), 19 (WF x Cop) F1, 16 backcross (BC) (F1 x WF) and 19 BC (F1 x Cop) females, at the age of 30 days. By 28 weeks after dusting, gross tumors were induced in 15 WF, 17 Cop, 12 (WF x Cop) F1, 11 BC (F1 x WF) and 14 BC (F1 x Cop) rats. Depending on their neoplastic response, carcinomatous response was 93% in WF, 5% in Cop, 16% in (WF x Cop) F1, 31% in BC (F1 x WF) and 0% in BC (Fl x Cop) rats, and sarcomatous response was 20% in WF, 85% in Cop, 58% in (WF x Cop) F1, 44% in BC (F1 x WF) and 73% in BC (F1 x Cop) rats. When dusting was performed on the interscapular fat tissue of 21 WF and 22 Cop females at 38 days of age, sarcomas were found in 67% of WF and 91% of Cop rats. Therefore, susceptibility and supressor gene(s) are suspected in mammary epithelial cells of the WF and Cop, respectively, for carcinogenesis, while co-dominant allele for sarcomagenesis exists in the Cop and WF mammary stromal cells.

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November 1992
Volume 1 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TAKAHASHI H, SHOJI T, TSUBURA A and MORII S: NEOPLASTIC RESPONSE TO DMBA POWDER IN MAMMARY AND INTERSCAPULAR TISSUES IN WISTAR FURTH AND COPENHAGEN FEMALE RATS. Int J Oncol 1: 657-659, 1992
APA
TAKAHASHI, H., SHOJI, T., TSUBURA, A., & MORII, S. (1992). NEOPLASTIC RESPONSE TO DMBA POWDER IN MAMMARY AND INTERSCAPULAR TISSUES IN WISTAR FURTH AND COPENHAGEN FEMALE RATS. International Journal of Oncology, 1, 657-659. https://doi.org/10.3892/ijo.1.6.657
MLA
TAKAHASHI, H., SHOJI, T., TSUBURA, A., MORII, S."NEOPLASTIC RESPONSE TO DMBA POWDER IN MAMMARY AND INTERSCAPULAR TISSUES IN WISTAR FURTH AND COPENHAGEN FEMALE RATS". International Journal of Oncology 1.6 (1992): 657-659.
Chicago
TAKAHASHI, H., SHOJI, T., TSUBURA, A., MORII, S."NEOPLASTIC RESPONSE TO DMBA POWDER IN MAMMARY AND INTERSCAPULAR TISSUES IN WISTAR FURTH AND COPENHAGEN FEMALE RATS". International Journal of Oncology 1, no. 6 (1992): 657-659. https://doi.org/10.3892/ijo.1.6.657