p53 mutation and protein overexpression in the early stages of esophageal tumorigenesis utilizing endoscopically obtained biopsy specimens

  • Authors:
    • G Kim
    • H Yamabe
    • Y ImadaShirakata
    • S Ueda
    • M Sakai
    • M Okuma
    • K Ishizaki
  • View Affiliations

  • Published online on: April 1, 1997     https://doi.org/10.3892/ijo.10.4.683
  • Pages: 683-688
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Abstract

It is unclear whether p53 abnormality in the early esophageal tumorigenesis causes clonal expansion with tumor growth. In this study, we analyzed p53 abnormalities by PCR-SSCP and immunohistochemistry in 86 esophageal endoscopic biopsy specimens. Eleven of 27 specimens (39%) of mild dysplasias showed p53 mutations. Six moderate or mild dysplasias were followed by endoscopy (average 73 weeks) and continually exhibited the same p53 mutation, but none of them showed apparent tumor growth and subepithelial epithelial invasion. These results suggest that p53 mutations occur very early in the esophageal tumorigenesis and contribute to cell proliferation, but cannot be related with malignant phenotype directly.

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April 1997
Volume 10 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kim G, Yamabe H, ImadaShirakata Y, Ueda S, Sakai M, Okuma M and Ishizaki K: p53 mutation and protein overexpression in the early stages of esophageal tumorigenesis utilizing endoscopically obtained biopsy specimens. Int J Oncol 10: 683-688, 1997
APA
Kim, G., Yamabe, H., ImadaShirakata, Y., Ueda, S., Sakai, M., Okuma, M., & Ishizaki, K. (1997). p53 mutation and protein overexpression in the early stages of esophageal tumorigenesis utilizing endoscopically obtained biopsy specimens. International Journal of Oncology, 10, 683-688. https://doi.org/10.3892/ijo.10.4.683
MLA
Kim, G., Yamabe, H., ImadaShirakata, Y., Ueda, S., Sakai, M., Okuma, M., Ishizaki, K."p53 mutation and protein overexpression in the early stages of esophageal tumorigenesis utilizing endoscopically obtained biopsy specimens". International Journal of Oncology 10.4 (1997): 683-688.
Chicago
Kim, G., Yamabe, H., ImadaShirakata, Y., Ueda, S., Sakai, M., Okuma, M., Ishizaki, K."p53 mutation and protein overexpression in the early stages of esophageal tumorigenesis utilizing endoscopically obtained biopsy specimens". International Journal of Oncology 10, no. 4 (1997): 683-688. https://doi.org/10.3892/ijo.10.4.683