Changes in chromosomes 1 and 6 associated with human cell immortalisation

  • Authors:
    • E Mitchell
    • A Kinsella
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/ijo.10.5.977
  • Pages: 977-981
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Abstract

A normal diploid human fibroblast cell line infected with HL60 c-myc has become immortal in vitro following continuous passage. At early passage post-infection the cells exhibited a normal diploid karyotype and in the absence of karyotypic changes grew well beyond the normal passage at which senescence occurred in the normal non-transfected parental cell line or the vector-infected control. Immortalisation of both the infected population and a subclone taken prior to karyotypic change was associated with two independent events involving chromosome 1. The subcloned population also possessed a deletion of the long arm of chromosome 6.

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May 1997
Volume 10 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mitchell E and Mitchell E: Changes in chromosomes 1 and 6 associated with human cell immortalisation. Int J Oncol 10: 977-981, 1997
APA
Mitchell, E., & Mitchell, E. (1997). Changes in chromosomes 1 and 6 associated with human cell immortalisation. International Journal of Oncology, 10, 977-981. https://doi.org/10.3892/ijo.10.5.977
MLA
Mitchell, E., Kinsella, A."Changes in chromosomes 1 and 6 associated with human cell immortalisation". International Journal of Oncology 10.5 (1997): 977-981.
Chicago
Mitchell, E., Kinsella, A."Changes in chromosomes 1 and 6 associated with human cell immortalisation". International Journal of Oncology 10, no. 5 (1997): 977-981. https://doi.org/10.3892/ijo.10.5.977