Involvement of human T lymphotropic virus type I in human neoplasia

  • Authors:
    • K Maruyama
    • M Miyauchi
    • S Mochizuki
    • K Kawamura
    • N Koshikawa
  • View Affiliations

  • Published online on: June 1, 1997     https://doi.org/10.3892/ijo.10.6.1157
  • Pages: 1157-1165
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Abstract

Of 211 human tissues analyzed by PCR-SSCP and direct sequencing for HTLV-I genes, 165 (78.2%) gave positive signals. Signals detected in family members of adult T cell leukemia (ATL) patients showed mutations distinct from those in ATL. HTLV-I gene sequences showed variability in same persons examined at different times. Lymphocytes with prototypic HTLV-I genes showed higher sister chromatid exchange following MNNG treatment than those without. Nasopharyngeal carcinomas carrying both HTLV-I and Epstein-Barr virus genes showed markedly abnormal gene product expression. HTLV-I genes in human DNA may cause deregulation of host cell genes upon exposure to carcinogens including viruses.

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June 1997
Volume 10 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Maruyama K, Miyauchi M, Mochizuki S, Kawamura K and Koshikawa N: Involvement of human T lymphotropic virus type I in human neoplasia. Int J Oncol 10: 1157-1165, 1997
APA
Maruyama, K., Miyauchi, M., Mochizuki, S., Kawamura, K., & Koshikawa, N. (1997). Involvement of human T lymphotropic virus type I in human neoplasia. International Journal of Oncology, 10, 1157-1165. https://doi.org/10.3892/ijo.10.6.1157
MLA
Maruyama, K., Miyauchi, M., Mochizuki, S., Kawamura, K., Koshikawa, N."Involvement of human T lymphotropic virus type I in human neoplasia". International Journal of Oncology 10.6 (1997): 1157-1165.
Chicago
Maruyama, K., Miyauchi, M., Mochizuki, S., Kawamura, K., Koshikawa, N."Involvement of human T lymphotropic virus type I in human neoplasia". International Journal of Oncology 10, no. 6 (1997): 1157-1165. https://doi.org/10.3892/ijo.10.6.1157