Preoperative prediction of postoperative reserve hepatic function for liver surgery for hepatobiliary, pancreatic cancer

  • Authors:
    • T Namieno
    • M Takahashi
    • K Koito
    • T Shimamura
    • N Sato
    • Y Une
    • K Yamashita
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/ijo.11.1.151
  • Pages: 151-155
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Abstract

To perform safer hepatic resection for hepatobiliary-pancreatic cancer, the possibility of preoperative prediction of postoperative reserve hepatic function was assessed using hepatobiliary scintigraphy. After intravenous administration of Tc-99m-pyridoxyl-5-methyltryptophan in 23 patients, the time-activity curves of region of interest over the heart and liver were generated, and peak and one-fourth clearance times were calculated, which were compared with biochemical data. The parameters were significantly related to protein syntheses (prothrombine time and hepaplastin test) and indocyanine-green dye excretion, but not to hepatobiliary enzymes. So we hypothesized 'when the curve left by subtracting the resected area from the whole liver was larger than one-third of the total liver curve, the surgery would be safe', which we applied to another eight patients, clarifying the hypothesis. Hepatobiliary scintigraphy can be a promising procedure in the assessment of partial liver function, and the study will contribute to a safer liver surgery.

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July 1997
Volume 11 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Namieno T, Takahashi M, Koito K, Shimamura T, Sato N, Une Y and Yamashita K: Preoperative prediction of postoperative reserve hepatic function for liver surgery for hepatobiliary, pancreatic cancer. Int J Oncol 11: 151-155, 1997
APA
Namieno, T., Takahashi, M., Koito, K., Shimamura, T., Sato, N., Une, Y., & Yamashita, K. (1997). Preoperative prediction of postoperative reserve hepatic function for liver surgery for hepatobiliary, pancreatic cancer. International Journal of Oncology, 11, 151-155. https://doi.org/10.3892/ijo.11.1.151
MLA
Namieno, T., Takahashi, M., Koito, K., Shimamura, T., Sato, N., Une, Y., Yamashita, K."Preoperative prediction of postoperative reserve hepatic function for liver surgery for hepatobiliary, pancreatic cancer". International Journal of Oncology 11.1 (1997): 151-155.
Chicago
Namieno, T., Takahashi, M., Koito, K., Shimamura, T., Sato, N., Une, Y., Yamashita, K."Preoperative prediction of postoperative reserve hepatic function for liver surgery for hepatobiliary, pancreatic cancer". International Journal of Oncology 11, no. 1 (1997): 151-155. https://doi.org/10.3892/ijo.11.1.151