High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer

  • Authors:
    • G CodacciPisanelli
    • P Seminara
    • L Gargano
    • M Accordino
    • E Sbaffi
    • V Bonaiuti
    • R Rossetti
    • F Franchi
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/ijo.11.1.25
  • Pages: 25-29
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Abstract

A chemotherapy regimen based on high doses of BCNU and mitomycin C with autologous bone marrow transplantation was used in 18 patients with advanced colorectal carcinoma. Haematological toxicity was manageable, with a short nadir for white blood cells and platelets. The response rate was 33%, with a prevalence in peritoneal lesions compared to liver or lung metastases. Extra-haematological toxicity appeared in 16% of cases: a case of veno-occlusive disease of the liver and two cases of lung impairment are discussed. Although the response rate obtained with the regimen was satisfactory, the more extensive use of high-dose chemotherapy followed by autologous bone marrow transplantation requires the identification of less toxic protocols.

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July 1997
Volume 11 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
CodacciPisanelli G, Seminara P, Gargano L, Accordino M, Sbaffi E, Bonaiuti V, Rossetti R and Franchi F: High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer. Int J Oncol 11: 25-29, 1997
APA
CodacciPisanelli, G., Seminara, P., Gargano, L., Accordino, M., Sbaffi, E., Bonaiuti, V. ... Franchi, F. (1997). High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer. International Journal of Oncology, 11, 25-29. https://doi.org/10.3892/ijo.11.1.25
MLA
CodacciPisanelli, G., Seminara, P., Gargano, L., Accordino, M., Sbaffi, E., Bonaiuti, V., Rossetti, R., Franchi, F."High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer". International Journal of Oncology 11.1 (1997): 25-29.
Chicago
CodacciPisanelli, G., Seminara, P., Gargano, L., Accordino, M., Sbaffi, E., Bonaiuti, V., Rossetti, R., Franchi, F."High-dose chemotherapy with bone marrow transplantation for advanced colorectal cancer". International Journal of Oncology 11, no. 1 (1997): 25-29. https://doi.org/10.3892/ijo.11.1.25