Differential expression of the neu transgene in murine mammary tissues

  • Authors:
    • K Deckard-Janatpour
    • W Muller
    • L Chodosh
    • H Gardner
    • S Marquis
    • R Coffey
    • R Cardiff
  • View Affiliations

  • Published online on: August 1, 1997     https://doi.org/10.3892/ijo.11.2.235
  • Pages: 235-241
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Abstract

The mammary glands of control FVB and mice with MTV-LTR promoted transgenes were stained using immunohistochemistry to detect neu expression. Neu expression in the terminal end buds of developing mammary glands and during early pregnancy in FVB mice was confirmed by in situ hybridization. Neu was expressed in all tumors from mice with the neu transgene but not in tumors expressing transforming growth factor alpha (TGF alpha) or polyoma virus middle T (PyV-MT). Neu was also expressed sporadically in non-neoplastic mammary cells of transgenic neu mice. However, most mammary cells expressing neu were dysplastic. The differential expression of the neu transgene has important implications for the interpretation of transgenic biology.

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August 1997
Volume 11 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Deckard-Janatpour K, Muller W, Chodosh L, Gardner H, Marquis S, Coffey R and Cardiff R: Differential expression of the neu transgene in murine mammary tissues. Int J Oncol 11: 235-241, 1997
APA
Deckard-Janatpour, K., Muller, W., Chodosh, L., Gardner, H., Marquis, S., Coffey, R., & Cardiff, R. (1997). Differential expression of the neu transgene in murine mammary tissues. International Journal of Oncology, 11, 235-241. https://doi.org/10.3892/ijo.11.2.235
MLA
Deckard-Janatpour, K., Muller, W., Chodosh, L., Gardner, H., Marquis, S., Coffey, R., Cardiff, R."Differential expression of the neu transgene in murine mammary tissues". International Journal of Oncology 11.2 (1997): 235-241.
Chicago
Deckard-Janatpour, K., Muller, W., Chodosh, L., Gardner, H., Marquis, S., Coffey, R., Cardiff, R."Differential expression of the neu transgene in murine mammary tissues". International Journal of Oncology 11, no. 2 (1997): 235-241. https://doi.org/10.3892/ijo.11.2.235