Up-regulation of nm23/NDP kinase expression in regenerating hepatocytes

  • Authors:
    • H Lee
    • K Okada
    • H Baba
    • K Furukawa
    • S Chang
    • H Shiku
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/ijo.11.5.965
  • Pages: 965-970
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Abstract

We analyzed the kinetics and subcellular localization of nm23-M1 and nm23-M2 in in vivo proliferating mouse liver cells after partial hepatectomy. Along with the regenerative growth rate measured by mitotic index, the expression of both nm23-M1 and nm23-M2 was altered with distinct kinetics. Among the subcellular fractions of regenerating hepatocytes, the increase in the quantity of nm23-M1 and nm23-M2 was the most dominant in the nuclear fractions. In in vitro proliferating human hepatocellular carcinoma cells (PLC/PRF/5) stimulated by hepatocyte growth factor, both nm23-H1 and nm23-H2 were dominantly accumulated around nuclear membranes.

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November 1997
Volume 11 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Lee H, Okada K, Baba H, Furukawa K, Chang S and Shiku H: Up-regulation of nm23/NDP kinase expression in regenerating hepatocytes. Int J Oncol 11: 965-970, 1997
APA
Lee, H., Okada, K., Baba, H., Furukawa, K., Chang, S., & Shiku, H. (1997). Up-regulation of nm23/NDP kinase expression in regenerating hepatocytes. International Journal of Oncology, 11, 965-970. https://doi.org/10.3892/ijo.11.5.965
MLA
Lee, H., Okada, K., Baba, H., Furukawa, K., Chang, S., Shiku, H."Up-regulation of nm23/NDP kinase expression in regenerating hepatocytes". International Journal of Oncology 11.5 (1997): 965-970.
Chicago
Lee, H., Okada, K., Baba, H., Furukawa, K., Chang, S., Shiku, H."Up-regulation of nm23/NDP kinase expression in regenerating hepatocytes". International Journal of Oncology 11, no. 5 (1997): 965-970. https://doi.org/10.3892/ijo.11.5.965