Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells.

  • Authors:
    • S Bardon
    • L Razanamahefa
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijo.12.2.355
  • Pages: 355-364
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Abstract

We examined the effects of all-trans retinoic acid (RA) on the insulin-induced cell growth, cell cycle progression and cyclin D1 gene expression in breast cancer cells. RA exerted a dose-dependent growth inhibition on insulin-induced proliferation in T47D and MCF-7 hormone-dependent cell lines, whereas MDA-MB231 hormone-independent cells were not affected. The RA antagonism of insulin growth effect was associated with an inhibition of cell cycle progression and a suppression of insulin-induced cyclin D1 mRNA. The effect of RA on cyclin D1 mRNA was dose-dependent and was observed within 5 h of treatment when insulin response was maximal.

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Feb 1998
Volume 12 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bardon S and Bardon S: Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells.. Int J Oncol 12: 355-364, 1998
APA
Bardon, S., & Bardon, S. (1998). Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells.. International Journal of Oncology, 12, 355-364. https://doi.org/10.3892/ijo.12.2.355
MLA
Bardon, S., Razanamahefa, L."Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells.". International Journal of Oncology 12.2 (1998): 355-364.
Chicago
Bardon, S., Razanamahefa, L."Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells.". International Journal of Oncology 12, no. 2 (1998): 355-364. https://doi.org/10.3892/ijo.12.2.355