Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.

  • Authors:
    • Y Oshika
    • M Nakamura
    • T Tokunaga
    • Y Ozeki
    • Y Fukushima
    • H Hatanaka
    • Y Abe
    • H Yamazaki
    • H Kijima
    • N Tamaoki
    • Y Ueyama
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.541
  • Pages: 541-545
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Abstract

Vascular endothelial growth factor (VEGF) has four isoforms (VEGF121, VEGF165, VEGF189, VEGF206). We examined the expression patterns of VEGF isoforms in non-small cell lung cancer (NSCLC) by RT-PCR. The cell-associated isoform VEGF189 was more frequently expressed in NSCLC (90.5%) than in extraneoplastic lung tissue (57.6%, p=0.00004). Immunohistochemical examination confirmed VEGF protein expression in 33 of 76 NSCLC expressing VEGF189 (V189p+ group). The V189p+ group showed significantly poorer prognosis than those without VEGF189 mRNA and protein (V189p- group, p=0.01722). These results suggest that expression of the cell-associated isoform VEGF189 is closely associated with progression of NSCLC.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Oshika Y, Nakamura M, Tokunaga T, Ozeki Y, Fukushima Y, Hatanaka H, Abe Y, Yamazaki H, Kijima H, Tamaoki N, Tamaoki N, et al: Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.. Int J Oncol 12: 541-545, 1998
APA
Oshika, Y., Nakamura, M., Tokunaga, T., Ozeki, Y., Fukushima, Y., Hatanaka, H. ... Ueyama, Y. (1998). Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.. International Journal of Oncology, 12, 541-545. https://doi.org/10.3892/ijo.12.3.541
MLA
Oshika, Y., Nakamura, M., Tokunaga, T., Ozeki, Y., Fukushima, Y., Hatanaka, H., Abe, Y., Yamazaki, H., Kijima, H., Tamaoki, N., Ueyama, Y."Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.". International Journal of Oncology 12.3 (1998): 541-545.
Chicago
Oshika, Y., Nakamura, M., Tokunaga, T., Ozeki, Y., Fukushima, Y., Hatanaka, H., Abe, Y., Yamazaki, H., Kijima, H., Tamaoki, N., Ueyama, Y."Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.". International Journal of Oncology 12, no. 3 (1998): 541-545. https://doi.org/10.3892/ijo.12.3.541