Glutathione-related mechanisms in cellular resistance to anticancer drugs.

  • Authors:
    • K Zhang
    • P Mack
    • K P Wong
  • View Affiliations

  • Published online on: April 1, 1998     https://doi.org/10.3892/ijo.12.4.871
  • Pages: 871-953
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Abstract

Glutathione conjugation and transport of glutathione conjugates of anticancer drugs out of cells have been shown to work as a system in the detoxification of many anticancer drugs. The major components of this system include glutathione (GSH), GSH-related enzymes and glutathione conjugate export pump (GS-X pump). GSH can combine with anticancer drugs to form less toxic and more water soluble GSH conjugates, the conjugation reaction is catalysed by glutathione S-transferases (GSTs). The GSH conjugates of anticancer drugs can be exported from cells by GS-X pump or multidrug resistance-associated protein (MRP). GSH, glutathione-related enzymes and GS-X pump or MRP have been found to be increased or overexpressed in many drug resistant cells. Increased detoxification of anticancer drugs by this system may confer drug resistance. Inhibition of this detoxification system is a strategy for modulation of drug resistance.

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Apr 1998
Volume 12 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zhang K, Mack P and Wong K: Glutathione-related mechanisms in cellular resistance to anticancer drugs.. Int J Oncol 12: 871-953, 1998
APA
Zhang, K., Mack, P., & Wong, K. (1998). Glutathione-related mechanisms in cellular resistance to anticancer drugs.. International Journal of Oncology, 12, 871-953. https://doi.org/10.3892/ijo.12.4.871
MLA
Zhang, K., Mack, P., Wong, K."Glutathione-related mechanisms in cellular resistance to anticancer drugs.". International Journal of Oncology 12.4 (1998): 871-953.
Chicago
Zhang, K., Mack, P., Wong, K."Glutathione-related mechanisms in cellular resistance to anticancer drugs.". International Journal of Oncology 12, no. 4 (1998): 871-953. https://doi.org/10.3892/ijo.12.4.871