Prognostic significance of cyclin expression in human osteosarcoma.

  • Authors:
    • L Molendini
    • M S Benassi
    • G Magagnoli
    • M Merli
    • M R Sollazzo
    • P Ragazzini
    • G Gamberi
    • C Ferrari
    • A Balladelli
    • P Bacchini
    • P Picci
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijo.12.5.1007
  • Pages: 1007-1018
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Abstract

To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% of the osteosarcomas, while immunostaining for cyclin D1 was weak or absent in most tumor samples. A positive, statistically significant correlation was found between A and E cyclins and Ki67 expression (p<0.001). Disease-free survival (DFS) analysis included 69 of the 92 patients. A significantly higher probability of metastasis was seen in patients lacking cyclin D1 compared to those in which cyclin D1 was positive (p<0.01). Conversely, patients with >40% of cyclin A-positive cells relapsed more frequently than those with <40% of cyclin A-positive cells (p<0.05). The multivariate analysis demonstrated that cyclin A had a lower predective risk in terms of disease-free survival as opposed to the loss of cyclin D1 that is considered a powerful prognostic factor.

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May 1998
Volume 12 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Molendini L, Benassi M, Magagnoli G, Merli M, Sollazzo M, Ragazzini P, Gamberi G, Ferrari C, Balladelli A, Bacchini P, Bacchini P, et al: Prognostic significance of cyclin expression in human osteosarcoma.. Int J Oncol 12: 1007-1018, 1998
APA
Molendini, L., Benassi, M., Magagnoli, G., Merli, M., Sollazzo, M., Ragazzini, P. ... Picci, P. (1998). Prognostic significance of cyclin expression in human osteosarcoma.. International Journal of Oncology, 12, 1007-1018. https://doi.org/10.3892/ijo.12.5.1007
MLA
Molendini, L., Benassi, M., Magagnoli, G., Merli, M., Sollazzo, M., Ragazzini, P., Gamberi, G., Ferrari, C., Balladelli, A., Bacchini, P., Picci, P."Prognostic significance of cyclin expression in human osteosarcoma.". International Journal of Oncology 12.5 (1998): 1007-1018.
Chicago
Molendini, L., Benassi, M., Magagnoli, G., Merli, M., Sollazzo, M., Ragazzini, P., Gamberi, G., Ferrari, C., Balladelli, A., Bacchini, P., Picci, P."Prognostic significance of cyclin expression in human osteosarcoma.". International Journal of Oncology 12, no. 5 (1998): 1007-1018. https://doi.org/10.3892/ijo.12.5.1007