Neoadjuvant chemotherapy with accelerated CNF plus G-CSF in patients with breast cancer tumors larger than three centimeters: a pilot study.

  • Authors:
    • V Lorusso
    • A Catino
    • F Schittulli
    • S Longo
    • A Racanelli
    • A Timurian
    • F Marzullo
    • G Simone
    • M Brandi
    • M De Lena
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijo.12.5.1177
  • Pages: 1177-1258
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Abstract

From February 1992 to November 1993, forty patients with operable breast cancer tumors larger than three centimeters were enrolled in this study of accelerated neo-adjuvant chemotherapy. Thirty-seven patients are evaluable: one patient was excluded from the protocol and two refused to continue treatment after the first cycle. Chemotherapy consisted of three presurgical cycles of CNF [cyclophosphamide at 600 mg/m2, mitoxantrone (Novantrone) at 10 mg/m2 and 5-fluorouracil at 600 mg/m2] administered every 2 weeks, plus G-CSF (5 microg/kg s.c./day on days 7-12). Twenty-six of 37 patients (70%) achieved objective tumor response and were submitted to quadrantectomy. Toxicity was easily manageable. After a median 55-month follow-up (range 48-70), no locoregional recurrences were observed. Distant metastases occurred in 12/37 (32%) patients. The five-year disease-free (DFS) and overall (OS) survival were 58% and 80%, respectively. Accelerated CNF plus G-CSF proved to be a safe and tolerable regimen yielding a good clinical response thereby increasing the possibility of breast conservation surgery for patients otherwise candidates for mastectomy.

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May 1998
Volume 12 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lorusso V, Catino A, Schittulli F, Longo S, Racanelli A, Timurian A, Marzullo F, Simone G, Brandi M, De Lena M, De Lena M, et al: Neoadjuvant chemotherapy with accelerated CNF plus G-CSF in patients with breast cancer tumors larger than three centimeters: a pilot study.. Int J Oncol 12: 1177-1258, 1998
APA
Lorusso, V., Catino, A., Schittulli, F., Longo, S., Racanelli, A., Timurian, A. ... De Lena, M. (1998). Neoadjuvant chemotherapy with accelerated CNF plus G-CSF in patients with breast cancer tumors larger than three centimeters: a pilot study.. International Journal of Oncology, 12, 1177-1258. https://doi.org/10.3892/ijo.12.5.1177
MLA
Lorusso, V., Catino, A., Schittulli, F., Longo, S., Racanelli, A., Timurian, A., Marzullo, F., Simone, G., Brandi, M., De Lena, M."Neoadjuvant chemotherapy with accelerated CNF plus G-CSF in patients with breast cancer tumors larger than three centimeters: a pilot study.". International Journal of Oncology 12.5 (1998): 1177-1258.
Chicago
Lorusso, V., Catino, A., Schittulli, F., Longo, S., Racanelli, A., Timurian, A., Marzullo, F., Simone, G., Brandi, M., De Lena, M."Neoadjuvant chemotherapy with accelerated CNF plus G-CSF in patients with breast cancer tumors larger than three centimeters: a pilot study.". International Journal of Oncology 12, no. 5 (1998): 1177-1258. https://doi.org/10.3892/ijo.12.5.1177